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knitted pink heart with a mended hole
CAR T Cells Mend Broken Mouse Hearts
Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.
CAR T Cells Mend Broken Mouse Hearts
CAR T Cells Mend Broken Mouse Hearts

Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.

Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.

heart failure
Pig Hearts Provide Long-Term Cardiac Function in Baboons
Ruth Williams | Dec 5, 2018 | 3 min read
Primates receiving heart transplants from genetically engineered pigs have survived more than six months, a new study reveals.
First iPS Cell Trial for Heart Disease Raises Excitement, Concern
Katarina Zimmer | Aug 31, 2018 | 4 min read
Without knowing the cells’ mechanism of action, researchers question the best way to administer them to patients.
Cardiac Cell Transplants Help Monkeys’ Hearts
Ashley Yeager | Jul 2, 2018 | 2 min read
The organ’s blood-pumping capacity improved with the infusion of cells, a study shows.
Why Afternoon Open Heart Surgery Is Better for Patient Outcomes
Catherine Offord | Oct 27, 2017 | 2 min read
Research in human patients and mice reveals the role of the circadian clock in the risk of heart damage at different times of day.
Image of the Day: Un-break My Heart
The Scientist Staff | Aug 8, 2017 | 1 min read
A failing heart is easily distinguished from a healthy one by numerous tell-tale signs, including its slender, stretched-out walls, increased size, and pooled blood clots.
Heart’s Backup Pacemaker Mechanisms Identified
Diana Kwon | Jul 28, 2017 | 2 min read
The sinoatrial node is home to multiple pacemakers that keep the heart beating if the main one falters.
In Failing Hearts, Cardiomyocytes Alter Metabolism
Amanda B. Keener | Jun 1, 2016 | 2 min read
While the heart cells normally burn fatty acids, when things go wrong ketones become the preferred fuel source.
The Fatty Acid–Ketone Switch
Amanda B. Keener | May 31, 2016 | 1 min read
In failing hearts, cardiomyocytes change their fuel preference.
If It Ain't Broke . . .
Kerry Grens | Jan 1, 2016 | 4 min read
Is there room to improve upon the tried-and-true, decades-old technology of artificial hearts?
Hearts in Hand
The Scientist Staff | Dec 31, 2015 | 1 min read
Texas Heart Institute heart surgeon Bud Frazier is a pioneer of heart transplant technologies.
Cell Transplants for Heart Questioned
Jef Akst | May 1, 2014 | 2 min read
A report reveals that using bone marrow stem cells to treat heart disease is less promising than a decade of research has let on.
Saving Failing Hearts
Kate Yandell | Mar 12, 2014 | 4 min read
Inhibiting a small regulatory RNA appears to improve cardiac function in mice with surgically induced heart problems.
Next Generation: Sensor-Laden Sheath to Monitor the Heart
Daniel Cossins | Feb 25, 2014 | 3 min read
A flexible, sensor-loaded membrane that fits snugly around the heart provides high-resolution monitoring of multiple cardiac health markers.
More Questionable Stem-Cell Science
Chris Palmer | Jun 18, 2013 | 2 min read
Disgraced stem-cell researcher Hisashi Moriguchi has published three new papers in BMJ Case Reports, including a rehashing of a retracted 2012 paper.
Blood Protein Rejuvenates Aging Heart
Dan Cossins | May 10, 2013 | 2 min read
A molecule found only in the blood of young mice dramatically reverses thickening and stiffening of the heart muscle in old mice.
Opinion: An Explosion of Devices
Stephen C. Schimpff | Jan 28, 2013 | 3 min read
From cardiovascular problems to neurological disorders, a plethora of new medical devices are reducing the need for surgery and improving the quality and safety of healthcare.
New Biological Pacemaker
Dan Cossins | Dec 18, 2012 | 1 min read
In guinea pigs, the insertion of a single gene can transform ordinary heart cells into pacemaker cells that regulate cardiac rhythm.
Omega-3s: Fishing for a Mechanism
Ethan J. Anderson and David A. Taylor | Nov 1, 2012 | 10+ min read
Despite abundant evidence supporting their ability to help prevent and treat cardiovascular disease, the therapeutic effectiveness of fish oil–derived fatty acids remains controversial.
A Lab on Everest
Bob Grant | Apr 23, 2012 | 1 min read
Mayo Clinic researchers set up shop in the Himalayas to study the physiology of climbers attempting to scale the world's highest peak.
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