Skip to main content

Conventional boundary crossed

Myosin IIB exhibits both conventional and unconventional myosin properties

Written byCathy Holding
| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00

The myosins are a large and diverse group of proteins that interact with actin to generate motility at the tissue level and within the subcellular environment, but only a few members of this superfamily have been characterized. In the July 25 Journal of Biological Chemistry, Steven Rosenfeld and colleagues at the University of Alabama report the biochemical analysis of the kinetics and enzymology of the myosin IIB isoform. Myosin II is the predominant class found in muscles and is historically referred to as "conventional" myosin; the other 19 classes are currently referred to as the "unconventional" myosins. The IIB isoform constitutes most of the myosin found in the central nervous system and all of the nonmuscle myosin in the heart. Their analyses reveal that myosin IIB, although a conventional myosin, exhibits properties of unconventional myosins (Journal of Biological Chemistry, DOI:10.1074/jbc.M302555200, July 25, 2003).

Rosenfeld et al. synthesized myosin IIB protein ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

Related articles background image
August 2026 Digest cover
August 2026

Epic Fail: Sea-Monkeys Sabotage Fieldwork

When Barry Hicks set out to photograph thrombolites, thousands of unexpected visitors photobombed his underwater images.

View this Issue
Overcoming Immunotherapy Resistance in Liver Cancer

Overcoming Immunotherapy Resistance in Liver Cancer

Axion Biosystems
Optimizing NGS Library Preparation for Reliable Sequencing Data

Optimizing NGS Library Preparation for Reliable Sequencing Data

Covaris
Using TCR Repertoire Sequencing to Advance Immunology Research

Using TCR Repertoire Sequencing to Advance Immunology Research

Miltenyi
Mapping Clonal Mosaicism in Aging Tissues

Mapping Clonal Mosaicism in Aging Tissues

Mission bio

Products

Sino Biological Logo

Sino Biological Launches SuperNuclease ® Pro with Free Trial Program

Sino Biological Logo

Sino Biological Launches Precisely Characterized Full-Length p-Tau217 Protein to Advance Next-Generation Alzheimer’s Biomarker Assay Development

A photo of a scientist placing the Resipher device on a 96-well plate.

Resipher: Continuous Live-Cell Mitochondrial Respiration Monitoring in 96-Well Plates

Lucid Scientific logo
Conceptual image of ice and frost.

The VAULT100 PRO: Inside the most advanced Stirling Ultracold ULT freezer ever built.

Stirling Ultracold logo