DNA Bends Control Gene Activation

Genomic structures called i-motifs signal DNA activation, while hairpin loops signal gene suppression.

Written byKerry Grens
| 2 min read

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WIKIMEDIA, STEPHEN COLEBOURNE

Bends in the genome called i-motifs, which look like a “W” folded in the middle along the Y axis, lead to the upregulation of a gene, while hairpins in the same location of a gene cause suppression, researchers reported recently at the American Chemical Society meeting in Dallas, Texas. “It’s the sort of evidence we’ve been waiting for” to help confirm the role of i-motifs, John Brazier of the University of Reading who was not part of the study, told Chemical & Engineering News.

In an associated paper, researchers led by ...

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  • kerry grens

    Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at WHYY in Philadelphia, and the health and science reporter at New Hampshire Public Radio. Kerry got her start in journalism as a AAAS Mass Media fellow at KUNC in Colorado. She has a master’s in biological sciences from Stanford University and a biology degree from Loyola University Chicago.

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