transcriptional regulation
Paused RNA Polymerase Quashes New Initiation of Transcription
Paused RNA Polymerase Quashes New Initiation of Transcription
Shawna Williams | Oct 1, 2017
Pauses may help cells fine-tune gene expression.
The Role of DNA Base Modifications
The Role of DNA Base Modifications
Skirmantas Kriaucionis | Sep 1, 2017
Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.
Infographic: The Various Forms of Methylated DNA
Infographic: The Various Forms of Methylated DNA
Skirmantas Kriaucionis | Aug 31, 2017
To expand the basic nucleotide alphabet, many species modify their DNA with epigenetic marks.
Nuclear Pores Come into Sharper Focus
Nuclear Pores Come into Sharper Focus
André Hoelz, Daniel H. Lin | Dec 1, 2016
Solving a long-standing structural puzzle will open the door to understanding one of the cell’s most enigmatic machines.
With CRISPR, Scientists Make Neurons From Fibroblasts
With CRISPR, Scientists Make Neurons From Fibroblasts
Kerry Grens | Aug 15, 2016
Researchers use the CRISPR/Cas system to express three transcription-factor genes, changing the identities of mouse cells.
Exercise Boosts Telomere Transcription
Exercise Boosts Telomere Transcription
Anna Azvolinsky | Jul 27, 2016
Endurance exercise and metabolism are linked to transcriptional activation of human telomeres, researchers propose.
Another Role for ApoE?
Another Role for ApoE?
Ashley P. Taylor | Jan 20, 2016
Key Alzheimer’s disease–related protein may be a transcriptional regulator.
Fearless about Folding
Fearless about Folding
Anna Azvolinsky | Jan 1, 2016
Susan Lindquist has never shied away from letting her curiosity guide her research career.
Shingo Kajimura: Fishing for Answers
Shingo Kajimura: Fishing for Answers
Karen Zusi | Nov 1, 2015
Assistant Professor, Department of Cell and Tissue Biology, University of California, San Francisco. Age: 39
CRISPR–Enabled Epigenome Editing
CRISPR–Enabled Epigenome Editing
Kerry Grens | Apr 6, 2015
Researchers apply the genome-editing technology to alter histones at distant gene enhancers, controlling gene expression.