Pauses may help cells fine-tune gene expression.

Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.

To expand the basic nucleotide alphabet, many species modify their DNA with epigenetic marks.

Solving a long-standing structural puzzle will open the door to understanding one of the cell’s most enigmatic machines.

Researchers use the CRISPR/Cas system to express three transcription-factor genes, changing the identities of mouse cells.

Endurance exercise and metabolism are linked to transcriptional activation of human telomeres, researchers propose.

Key Alzheimer’s disease–related protein may be a transcriptional regulator.

Susan Lindquist has never shied away from letting her curiosity guide her research career.

Assistant Professor, Department of Cell and Tissue Biology, University of California, San Francisco. Age: 39

Researchers apply the genome-editing technology to alter histones at distant gene enhancers, controlling gene expression.