Left-Handed DNA Has a Biological Role Within a Dynamic Genetic Code
Left-Handed DNA Has a Biological Role Within a Dynamic Genetic Code
Once considered an unimportant curiosity, Z-DNA is now recognized to provide an on-the-fly mechanism to regulate how an RNA transcript is edited.
Left-Handed DNA Has a Biological Role Within a Dynamic Genetic Code
Left-Handed DNA Has a Biological Role Within a Dynamic Genetic Code

Once considered an unimportant curiosity, Z-DNA is now recognized to provide an on-the-fly mechanism to regulate how an RNA transcript is edited.

Once considered an unimportant curiosity, Z-DNA is now recognized to provide an on-the-fly mechanism to regulate how an RNA transcript is edited.

transcriptional regulation
Infographic: DNA Isn’t Always Right-Handed
Infographic: DNA Isn’t Always Right-Handed
Rachel Brazil | Jun 1, 2020
When the nucleic acid spirals to the left, it takes on a zig-zag shape known as Z-DNA that appears to regulate RNA editing.
Image of the Day: Switch Gears
Image of the Day: Switch Gears
Sukanya Charuchandra | Sep 10, 2018
A gene responsible for the free-moving, primitive nature of fetal cells is expressed in some breast cancer cells in mice and humans.
Paused RNA Polymerase Quashes New Initiation of Transcription
Paused RNA Polymerase Quashes New Initiation of Transcription
Shawna Williams | Sep 30, 2017
Pauses may help cells fine-tune gene expression.
The Role of DNA Base Modifications
The Role of DNA Base Modifications
Skirmantas Kriaucionis | Aug 31, 2017
Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.
Infographic: The Various Forms of Methylated DNA
Infographic: The Various Forms of Methylated DNA
Skirmantas Kriaucionis | Aug 31, 2017
To expand the basic nucleotide alphabet, many species modify their DNA with epigenetic marks.
Nuclear Pores Come into Sharper Focus
Nuclear Pores Come into Sharper Focus
André Hoelz, Daniel H. Lin | Nov 30, 2016
Solving a long-standing structural puzzle will open the door to understanding one of the cell’s most enigmatic machines.
With CRISPR, Scientists Make Neurons From Fibroblasts
With CRISPR, Scientists Make Neurons From Fibroblasts
Kerry Grens | Aug 15, 2016
Researchers use the CRISPR/Cas system to express three transcription-factor genes, changing the identities of mouse cells.
Exercise Boosts Telomere Transcription
Exercise Boosts Telomere Transcription
Anna Azvolinsky | Jul 27, 2016
Endurance exercise and metabolism are linked to transcriptional activation of human telomeres, researchers propose.
Another Role for ApoE?
Another Role for ApoE?
Ashley P. Taylor | Jan 20, 2016
Key Alzheimer’s disease–related protein may be a transcriptional regulator.