Signaling Dynamics Fine-Tune Gene Expression
Signaling Dynamics Fine-Tune Gene Expression
The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.
Signaling Dynamics Fine-Tune Gene Expression
Signaling Dynamics Fine-Tune Gene Expression

The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.

The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.

transcriptional regulation
Left-Handed DNA Has a Biological Role Within a Dynamic Genetic Code
Left-Handed DNA Has a Biological Role Within a Dynamic Genetic Code
Rachel Brazil | Jun 1, 2020
Once considered an unimportant curiosity, Z-DNA is now recognized to provide an on-the-fly mechanism to regulate how an RNA transcript is edited.
Infographic: DNA Isn’t Always Right-Handed
Infographic: DNA Isn’t Always Right-Handed
Rachel Brazil | Jun 1, 2020
When the nucleic acid spirals to the left, it takes on a zig-zag shape known as Z-DNA that appears to regulate RNA editing.
Image of the Day: Switch Gears
Image of the Day: Switch Gears
Sukanya Charuchandra | Sep 10, 2018
A gene responsible for the free-moving, primitive nature of fetal cells is expressed in some breast cancer cells in mice and humans.
Paused RNA Polymerase Quashes New Initiation of Transcription
Paused RNA Polymerase Quashes New Initiation of Transcription
Shawna Williams | Oct 1, 2017
Pauses may help cells fine-tune gene expression.
The Role of DNA Base Modifications
The Role of DNA Base Modifications
Skirmantas Kriaucionis | Sep 1, 2017
Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.
Infographic: The Various Forms of Methylated DNA
Infographic: The Various Forms of Methylated DNA
Skirmantas Kriaucionis | Aug 31, 2017
To expand the basic nucleotide alphabet, many species modify their DNA with epigenetic marks.
Nuclear Pores Come into Sharper Focus
Nuclear Pores Come into Sharper Focus
André Hoelz, Daniel H. Lin | Dec 1, 2016
Solving a long-standing structural puzzle will open the door to understanding one of the cell’s most enigmatic machines.
With CRISPR, Scientists Make Neurons From Fibroblasts
With CRISPR, Scientists Make Neurons From Fibroblasts
Kerry Grens | Aug 15, 2016
Researchers use the CRISPR/Cas system to express three transcription-factor genes, changing the identities of mouse cells.
Exercise Boosts Telomere Transcription
Exercise Boosts Telomere Transcription
Anna Azvolinsky | Jul 27, 2016
Endurance exercise and metabolism are linked to transcriptional activation of human telomeres, researchers propose.
Another Role for ApoE?
Another Role for ApoE?
Ashley P. Taylor | Jan 20, 2016
Key Alzheimer’s disease–related protein may be a transcriptional regulator.
Fearless about Folding
Fearless about Folding
Anna Azvolinsky | Jan 1, 2016
Susan Lindquist has never shied away from letting her curiosity guide her research career.
Shingo Kajimura: Fishing for Answers
Shingo Kajimura: Fishing for Answers
Karen Zusi | Nov 1, 2015
Assistant Professor, Department of Cell and Tissue Biology, University of California, San Francisco. Age: 39
CRISPR–Enabled Epigenome Editing
CRISPR–Enabled Epigenome Editing
Kerry Grens | Apr 6, 2015
Researchers apply the genome-editing technology to alter histones at distant gene enhancers, controlling gene expression.
Enhanced Enhancers
Enhanced Enhancers
Eric Olson | Nov 1, 2014
The recent discovery of super-enhancers may offer new drug targets for a range of diseases.
Next Generation: Freeze-Dried Gene Networks
Next Generation: Freeze-Dried Gene Networks
Jef Akst | Oct 23, 2014
Researchers devise a way to preserve bits of paper containing synthetic gene networks, which can be easily stored and widely distributed. Rehydrated, transcription and translation “come to life.”
Female Pigs May Sense Sex of Sperm
Female Pigs May Sense Sex of Sperm
Anna Azvolinsky | May 21, 2014
The oviducts of pigs exhibit different gene expression profiles depending on their exposure to sperm with either an X or a Y chromosome, a study shows. 
Exploring the Roles of Enhancer RNAs
Exploring the Roles of Enhancer RNAs
Ashley P. Taylor | May 7, 2014
Scientists have recently discovered that enhancers are often transcribed into RNAs. But they’re still not sure what, if anything, these eRNAs do.
Week in Review: March 31–April 4
Week in Review: March 31–April 4
Tracy Vence | Apr 4, 2014
Transcriptional landscape of the fetal brain; how a parasitic worm invades plants; difficulties reproducing “breakthrough” heart regeneration method; oxytocin and dishonesty
Enhancer and Promoter Atlases
Enhancer and Promoter Atlases
Ashley P. Taylor | Mar 26, 2014
Consortium annotates the human genome with cell type-specific information about transcription start sites, active enhancers, and their expression throughout the body.