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CRISPR–Enabled Epigenome Editing
Kerry Grens | Apr 6, 2015
Researchers apply the genome-editing technology to alter histones at distant gene enhancers, controlling gene expression.
Eric Olson | Nov 1, 2014
The recent discovery of super-enhancers may offer new drug targets for a range of diseases.
Next Generation: Freeze-Dried Gene Networks
Jef Akst | Oct 23, 2014
Researchers devise a way to preserve bits of paper containing synthetic gene networks, which can be easily stored and widely distributed. Rehydrated, transcription and translation “come to life.”
Female Pigs May Sense Sex of Sperm
Anna Azvolinsky | May 21, 2014
The oviducts of pigs exhibit different gene expression profiles depending on their exposure to sperm with either an X or a Y chromosome, a study shows.
Exploring the Roles of Enhancer RNAs
Ashley P. Taylor | May 7, 2014
Scientists have recently discovered that enhancers are often transcribed into RNAs. But they’re still not sure what, if anything, these eRNAs do.
Week in Review: March 31–April 4
Tracy Vence | Apr 4, 2014
Transcriptional landscape of the fetal brain; how a parasitic worm invades plants; difficulties reproducing “breakthrough” heart regeneration method; oxytocin and dishonesty
Enhancer and Promoter Atlases
Ashley P. Taylor | Mar 26, 2014
Consortium annotates the human genome with cell type-specific information about transcription start sites, active enhancers, and their expression throughout the body.
DNA Bends Control Gene Activation
Kerry Grens | Mar 25, 2014
Genomic structures called i-motifs signal DNA activation, while hairpin loops signal gene suppression.
DNA Damage Scout
Andrew P. Han | Feb 11, 2014
Researchers are beginning to appreciate a role for RNA polymerase beyond gene transcription.
Daytime Sleep Alters Human Transcriptome
Jef Akst | Jan 20, 2014
A mistimed sleep cycle drastically reduces the number of genes that are expressed in a 24-hour rhythm.