DNA Methylation Influences Replication and Genome Organization
DNA Methylation Influences Replication and Genome Organization
A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.
DNA Methylation Influences Replication and Genome Organization
DNA Methylation Influences Replication and Genome Organization

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.

gene expression
Signaling Dynamics Fine-Tune Gene Expression
Signaling Dynamics Fine-Tune Gene Expression
Ruth Williams | Sep 3, 2021
The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.
Tool Would Use Tumor Gene Expression to Inform Radiation Dose
Tool Would Use Tumor Gene Expression to Inform Radiation Dose
Alejandra Manjarrez | Aug 27, 2021
In a retrospective analysis, a team found that an algorithm integrating the gene expression of a tumor with the radiation dose a patient received predicted how well the patient responded to the treatment.
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Abby Olena | Aug 18, 2021
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
Many Bacteria and Archaea Promoters Work Forward and Backward
Many Bacteria and Archaea Promoters Work Forward and Backward
Jack J. Lee | May 28, 2021
New analyses find that divergent transcription, in which one promoter directs the expression of two adjacent genes oriented in opposite directions, is conserved across all domains of life.
Siobhán Brady Uses Big Data to Investigate Plant Development
Siobhán Brady Uses Big Data to Investigate Plant Development
Shawna Williams | Feb 1, 2021
The University of California, Davis, professor is a pioneer in teasing apart the changes in gene expression that drive root development.
Eight Proteins Turn Mouse Stem Cells into Egglike Cells
Eight Proteins Turn Mouse Stem Cells into Egglike Cells
Ashley Yeager | Dec 16, 2020
The identification of the transcription factors that elicit oocyte growth will aid reproductive biology research and might help women with fertility issues, scientists say.  
Regulators of Gene Activity in Animals Are Deeply Conserved
Regulators of Gene Activity in Animals Are Deeply Conserved
Amanda Heidt | Nov 6, 2020
Enhancers, short regions of DNA that direct gene expression, of species separated by 700 million years of evolution worked interchangeably, according to a new study.
New Map Charts Genetic Expression Across Tissue Types, Sexes
New Map Charts Genetic Expression Across Tissue Types, Sexes
Ashley Yeager | Sep 10, 2020
A decade-long effort to probe gene regulation reveals differences between males and females, points to essential regulatory elements, and offers insight into past work on telomeres.
Receptors for SARS-CoV-2 Present in Wide Variety of Human Cells
Receptors for SARS-CoV-2 Present in Wide Variety of Human Cells
Chris Baraniuk | Apr 29, 2020
Analyses from single-cell sequencing datasets support the idea that COVID-19 is not just a respiratory disease but an illness that can affect multiple organs.
Infographic: How Some X-Chromosome Genes Escape Inactivation
Infographic: How Some X-Chromosome Genes Escape Inactivation
Amber Dance | Mar 1, 2020
About one-quarter of the hundreds of genes on the inactivated X chromosome in XX cells manage to escape that silencing, at least some of the time.
Genes that Escape Silencing on the Second X Chromosome May Drive Disease
Genes that Escape Silencing on the Second X Chromosome May Drive Disease
Amber Dance | Mar 1, 2020
When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.
The Advances that Will Shape Life Sciences in the 2020s
The Advances that Will Shape Life Sciences in the 2020s
Emma Yasinski | Jan 3, 2020
Systems biologist Steven Wiley says advancements in two areas—single-cell biology and CRISPR—are poised to transform research.  
Image of the Day: Reprogrammed Ants
Image of the Day: Reprogrammed Ants
Emily Makowski | Nov 13, 2019
Watch soldier ants behave more like foragers after scientists change their gene expression.