Photo of Makio Murayama
Handmade Hemoglobin, 1912-2012
Makio Murayama, a Japanese-American biochemist who was turned away from the Manhattan Project due to his heritage, rose to prominence for his work uncovering the link between the structure of hemoglobin and the mechanisms of sickle cell disease.
Handmade Hemoglobin, 1912-2012
Handmade Hemoglobin, 1912-2012

Makio Murayama, a Japanese-American biochemist who was turned away from the Manhattan Project due to his heritage, rose to prominence for his work uncovering the link between the structure of hemoglobin and the mechanisms of sickle cell disease.

Makio Murayama, a Japanese-American biochemist who was turned away from the Manhattan Project due to his heritage, rose to prominence for his work uncovering the link between the structure of hemoglobin and the mechanisms of sickle cell disease.

structural biology
Infographic about SLiMs in SARS-CoV-2 Infection
Infographic: Short Protein Motifs’ Role in SARS-CoV-2 Infection
Conchita Fraguas Bringas and Jakob Nilsson | May 16, 2022
Known as SLiMs, these stretches of up to 10 amino acids play notable roles in cell biology, including responses to viral invasion.
Donald Caspar smiling into camera holding a buckyball model
Legendary Crystallographer Donald Caspar Dies At 94
Lisa Winter | Jan 7, 2022
He coined the term “structural biology.”
Explore how scientists determine the atomic structures of protein aggregates
Revolutionizing Neurodegeneration Research with Cryo-EM
The Scientist Creative Services Team and Thermo Fisher Scientific
Advancements in cryo-EM technology allow researchers to develop drugs and diagnostic tools for neurodegenerative diseases.
A side-by-side illustration of bacterial nanotubes, conjugative pili, and type 3 secretion systems such as injectisomes and flagella
Infographic: What Are Bacterial Nanotubes?
Sruthi S. Balakrishnan | Jun 1, 2021
Unlike other cellular appendages, bacterial nanotubes are made solely of lipids and can connect the cytoplasm of different microbial species.
chrystal starbird
From Nature Lover to Structural Biologist: A Scientist’s Journey
Asher Jones | Feb 26, 2021
A gift of medical books from an unlikely source spurred Chrystal Starbird’s scientific career. She talks about what motivates her research on cell surface receptors and the obstacles she has faced as a Black woman in academia.
Understanding Cancer Using Cryo-EM
Understanding the Complexity of Cancer with Cryo-EM
The Scientist Creative Services Team and Thermo Fisher Scientific
Explore how researchers use cryogenic electron microscopy (cryo-EM) to identify how mutations affect protein signaling and function through structural or conformational changes.
Spike Structure Gives Insight into SARS-CoV-2 Evolution
Abby Olena | Jul 16, 2020
Researchers demonstrate that the SARS-CoV-2 spike protein is more stable and binds the human ACE2 receptor with much higher affinity than the spike protein of its closest known relative, bat coronavirus RaTG13.
Left-Handed DNA Has a Biological Role Within a Dynamic Genetic Code
Rachel Brazil | Jun 1, 2020
Once considered an unimportant curiosity, Z-DNA is now recognized to provide an on-the-fly mechanism to regulate how an RNA transcript is edited.
Form Determines Function: Insights from Structural Biology
The Scientist Creative Services Team
Researchers use diverse tools to analyze protein structures.
coronavirus sars-cov-2 spike protein covid-19 structure glycans ace2 furin antibody
Scientists Scan for Weaknesses in the SARS-CoV-2 Spike Protein
Chris Baraniuk | Apr 9, 2020
The virus’s tool for prying open host cells is coated in a protective armor of sugar—but gaps may offer vulnerability to disruption by antibodies.
Image of the Day: Chromatin Forest
Emily Makowski | Jan 14, 2020
The DNA-protein complex has branches that fold back on themselves.
Transforming Virology Research with Cryo-EM
The Scientist Creative Services Team and Thermo Fisher Scientific
Explore what researchers can do with Cryo-EM
Chemist Christopher Dobson Dies
Ashley Yeager | Sep 16, 2019
The University of Cambridge scholar’s research on folding proteins advanced scientists’ understanding of illnesses, such as Alzheimer’s disease, Parkinson’s disease, and type 2 diabetes.
Barbara Low, Trailblazing Woman in X-Ray Crystallography, Dies
Carolyn Wilke | Mar 15, 2019
The former Columbia University professor’s early work helped illuminate the structure of penicillin, allowing chemists to make variants and broaden the scope of antibiotic treatments.
Fast-Tracking COVID-19 Research
The Scientist Creative Services Team in collaboration with Sartorius Corporation
Identifying molecular targets for SARS-CoV-2 therapeutics.
Book Excerpt from Gene Machine
Venki Ramakrishnan | Dec 5, 2018
In Chapter 13, “The Final Assault,” author Venki Ramakrishnan relays the moment when he and collaborators finally solved the structure of a ribosomal subunit.
Racing for the Ribosome
Venki Ramakrishnan | Dec 1, 2018
Nobel laureate Venki Ramakrishnan’s new book recounts the tale of researchers striving to understand an ancient molecular machine that is essential for all life.
Image of the Day: Viral Vision
Sukanya Charuchandra | Sep 18, 2018
Modified cryogenic electron microscopy can analyze viral structures better than ever before.
“Public” T-Cell Receptors From Resistant People Fend Off HIV
Shawna Williams | Jun 8, 2018
The receptors, found in so-called elite controllers who don’t need medications to keep the virus in check, suggest a new path toward immunotherapy.