Spike Structure Gives Insight into SARS-CoV-2 Evolution
Spike Structure Gives Insight into SARS-CoV-2 Evolution
Researchers demonstrate that the SARS-CoV-2 spike protein is more stable and binds the human ACE2 receptor with much higher affinity than the spike protein of its closest known relative, bat coronavirus RaTG13.
Spike Structure Gives Insight into SARS-CoV-2 Evolution
Spike Structure Gives Insight into SARS-CoV-2 Evolution

Researchers demonstrate that the SARS-CoV-2 spike protein is more stable and binds the human ACE2 receptor with much higher affinity than the spike protein of its closest known relative, bat coronavirus RaTG13.

Researchers demonstrate that the SARS-CoV-2 spike protein is more stable and binds the human ACE2 receptor with much higher affinity than the spike protein of its closest known relative, bat coronavirus RaTG13.

structural biology
Left-Handed DNA Has a Biological Role Within a Dynamic Genetic Code
Left-Handed DNA Has a Biological Role Within a Dynamic Genetic Code
Rachel Brazil | Jun 1, 2020
Once considered an unimportant curiosity, Z-DNA is now recognized to provide an on-the-fly mechanism to regulate how an RNA transcript is edited.
Scientists Scan for Weaknesses in the SARS-CoV-2 Spike Protein
Scientists Scan for Weaknesses in the SARS-CoV-2 Spike Protein
Chris Baraniuk | Apr 9, 2020
The virus’s tool for prying open host cells is coated in a protective armor of sugar—but gaps may offer vulnerability to disruption by antibodies.
Image of the Day: Chromatin Forest
Image of the Day: Chromatin Forest
Emily Makowski | Jan 14, 2020
The DNA-protein complex has branches that fold back on themselves.
Chemist Christopher Dobson Dies
Chemist Christopher Dobson Dies
Ashley Yeager | Sep 16, 2019
The University of Cambridge scholar’s research on folding proteins advanced scientists’ understanding of illnesses, such as Alzheimer’s disease, Parkinson’s disease, and type 2 diabetes.
Barbara Low, Trailblazing Woman in X-Ray Crystallography, Dies
Barbara Low, Trailblazing Woman in X-Ray Crystallography, Dies
Carolyn Wilke | Mar 15, 2019
The former Columbia University professor’s early work helped illuminate the structure of penicillin, allowing chemists to make variants and broaden the scope of antibiotic treatments.
Book Excerpt from <em>Gene Machine</em>
Book Excerpt from Gene Machine
Venki Ramakrishnan | Dec 5, 2018
In Chapter 13, “The Final Assault,” author Venki Ramakrishnan relays the moment when he and collaborators finally solved the structure of a ribosomal subunit.
Racing for the Ribosome
Racing for the Ribosome
Venki Ramakrishnan | Nov 30, 2018
Nobel laureate Venki Ramakrishnan’s new book recounts the tale of researchers striving to understand an ancient molecular machine that is essential for all life.
Image of the Day: Viral Vision
Image of the Day: Viral Vision
Sukanya Charuchandra | Sep 18, 2018
Modified cryogenic electron microscopy can analyze viral structures better than ever before.
“Public” T-Cell Receptors From Resistant People Fend Off HIV
“Public” T-Cell Receptors From Resistant People Fend Off HIV
Shawna Williams | Jun 8, 2018
The receptors, found in so-called elite controllers who don’t need medications to keep the virus in check, suggest a new path toward immunotherapy.