Identifying molecular targets for SARS-CoV-2 therapeutics.

Researchers demonstrate that the SARS-CoV-2 spike protein is more stable and binds the human ACE2 receptor with much higher affinity than the spike protein of its closest known relative, bat coronavirus RaTG13.

Once considered an unimportant curiosity, Z-DNA is now recognized to provide an on-the-fly mechanism to regulate how an RNA transcript is edited.

The virus’s tool for prying open host cells is coated in a protective armor of sugar—but gaps may offer vulnerability to disruption by antibodies.

The DNA-protein complex has branches that fold back on themselves.

The University of Cambridge scholar’s research on folding proteins advanced scientists’ understanding of illnesses, such as Alzheimer’s disease, Parkinson’s disease, and type 2 diabetes.

The former Columbia University professor’s early work helped illuminate the structure of penicillin, allowing chemists to make variants and broaden the scope of antibiotic treatments.

In Chapter 13, “The Final Assault,” author Venki Ramakrishnan relays the moment when he and collaborators finally solved the structure of a ribosomal subunit.

Nobel laureate Venki Ramakrishnan’s new book recounts the tale of researchers striving to understand an ancient molecular machine that is essential for all life.