From Many, One

Diverse mammals, including humans, have been found to carry distinct genomes in their cells. What does such genetic chimerism mean for health and disease?

| 14 min read

Register for free to listen to this article
Listen with Speechify
0:00
14:00
Share

M.C ESCHER'S "BOND OF UNION" © 2015 THE M.C ESCHER COMPANY — THE NETHERLANDS. ALL RIGHTS RESERVED. WWW.MCESCHER.COM

In 1976, researchers from the Lister Institute of Preventive Medicine in London published the puzzling case of a woman who had two different blood types: 93 percent of her red cells were type O, while the remaining 7 percent were type A1, the most common type A subgroup.1 A few years later, Winifred Watkins of the MRC Clinical Research Centre and colleagues came across another blood donor with two distinct red blood cell types, and further investigation led to an even more astonishing finding: a phenotypically normal man, with presumably XY cells in his testes and most of his body, was found to carry XX cells in his skin and other tissues.2

These case studies heralded a new appreciation for the phenomenon of genetic chimerism—when ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • Elena E. Giorgi

    This person does not yet have a bio.

Published In

Share
May digest 2025 cover
May 2025, Issue 1

Study Confirms Safety of Genetically Modified T Cells

A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.

View this Issue
iStock

TaqMan Probe & Assays: Unveil What's Possible Together

Thermo Fisher Logo
Meet Aunty and Tackle Protein Stability Questions in Research and Development

Meet Aunty and Tackle Protein Stability Questions in Research and Development

Unchained Labs
Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
How technology makes PCR instruments easier to use.

Making Real-Time PCR More Straightforward

Thermo Fisher Logo

Products

fujirebio-square-logo

Fujirebio Receives Marketing Clearance for Lumipulse® G pTau 217/ β-Amyloid 1-42 Plasma Ratio In-Vitro Diagnostic Test

The Scientist Placeholder Image

Biotium Launches New Phalloidin Conjugates with Extended F-actin Staining Stability for Greater Imaging Flexibility

Leica Microsystems Logo

Latest AI software simplifies image analysis and speeds up insights for scientists

BioSkryb Genomics Logo

BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours