Genetically Modified Viral Cocktail Treats Deadly Bacteria in Teen

Tweaking the genomes of two phages and combining them with a third phage helped to clear a persistent Mycobacterium infection in the patient.

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ABOVE: Three phages called Muddy, BPs, and ZoeJ (shown left to right in electron micrographs) were used to treat a patient’s bacterial infection.
R. M. DEDRICK ET AL./NATURE MEDICINE 2019

Genetically modified viruses have successfully treated an antibiotic-resistant infection in a teenage girl, saving her life, researchers report today (May 8) in Nature Medicine. While this approach using engineered phages—viruses that infect bacteria—has only been tested in one person, the technique could be developed to battle other persistent, “superbug” infections.

“This is actually a historic moment,” Steffanie Strathdee, a professor of medicine at the University of California, San Diego, who was not involved in the study, tells NPR. “This is the first time that a genetically engineered phage has been used to successfully treat a superbug infection in a human being.” Strathdee says. “It’s terribly exciting.”

In the study, a teenager from England was suffering from an infection with a strain ...

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  • Ashley Yeager

    Ashley started at The Scientist in 2018. Before joining the staff, she worked as a freelance editor and writer, a writer at the Simons Foundation, and a web producer at Science News, among other positions. She holds a bachelor’s degree in journalism from the University of Tennessee, Knoxville, and a master’s degree in science writing from MIT. Ashley edits the Scientist to Watch and Profile sections of the magazine and writes news, features, and other stories for both online and print.

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