In cells with normal satellite DNA–binding proteins, chromocenters pull several chromosomes together.
When the function of the DNA-binding proteins is experimentally altered, chromocenter formation also changes.
|Elimination of satellite DNA–binding proteins
|Overexpression of satellite DNA–binding proteins
|Protein binding to abnormal sites
|Chromocenters cannot form; chromosomes bleb away from the nucleus in micronuclei
|Chromosomes gather in larger bunches than normal, limiting the number of chromocenters formed
|All regions in contact with the DNA-binding proteins are pulled into chromocenters
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