In cells with normal satellite DNA–binding proteins, chromocenters pull several chromosomes together.

© lucy reading-ikkanda

When the function of the DNA-binding proteins is experimentally altered, chromocenter formation also changes.

© lucy reading-ikkanda
Elimination of satellite DNA–binding proteins
Overexpression of satellite DNA–binding proteins
Protein binding to abnormal sites
Chromocenters cannot form; chromosomes bleb away from the nucleus in micronuclei
Chromosomes gather in larger bunches than normal, limiting the number of chromocenters formed
All regions in contact with the DNA-binding proteins are pulled into chromocenters

Read the full story.

Interested in reading more?

Magaizne Cover

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!