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Infographic showing how bursting micronuclei promote cancer

Infographic: Chromosome Errors Cause Micronuclei and Drive Cancer

Samuel F. Bakhoum | Mar 1, 2022

When micronuclei rupture, chromosomes break, recombine, and form circles, causing inflammation and promoting carcinogenic growth.

Chromosomal Rearrangement Linked to Less Mobile Quail

Chloe Tenn | Dec 7, 2021

The Scientist interviews evolutionary biologist Carles Vilà about how a large genomic inversion detected in common quail affects the birds’ physical characteristics and migratory behaviors.

Bridging Disciplines to Study CRISPR-Induced Chromosome Destabilization

Aparna Nathan | Apr 8, 2022

A collaboration between friends led to a cautionary finding about CRISPR’s effect on cells.

Five morphs of Poecilia parae—from top: melanzona yellow, melanzona blue, melanzona red, parae, immaculata—and a female (bottom) of the same species

Fish Species’ Y Chromosomes Diverged Even Without Recombination

Catherine Offord | Sep 1, 2021

Researchers discover surprisingly high levels of genetic diversity among the colorful male morphs of a freshwater fish.

Cell Biologist Angelika Amon Dies at 53

Max Kozlov | Nov 4, 2020

A “larger than life personality,” Amon devoted her career to studying the cell cycle and aneuploidy. Her research has shaped the field of cancer biology.

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Investigating Genetic and Epigenetic Landscapes with Long-Read Sequencing

The Scientist Creative Services Team in collaboration with Oxford Nanopore | Aug 13, 2021

Matthew Naish will discuss what he learned about Arabidopsis thaliana centromeres from long-read sequencing experiments.

Michelle Gray Tracks Huntington’s in Different Brain Cells

Amanda Heidt | Oct 1, 2020

The University of Alabama at Birmingham neuroscientist aims to determine which cells are most important in prompting the disease’s initiation and progression.

gene, CRISPR, CRISPR-Cas9, gene editing, human embryo, chromosome, mutation, deletion

CRISPR Gene Editing Prompts Chaos in DNA of Human Embryos

Amanda Heidt | Jun 26, 2020

Three studies identify unintended consequences of gene editing in human embryos, including large deletions and reshuffling of DNA.

Scaling BAC on Time and Sample

The Scientist Creative Services Team in collaboration with Agilent Technologies | Apr 9, 2021

A new and simplified quality control method confirms the cloning of both small and large inserts in bacterial artificial chromosomes (BACs) with significantly less time and sample.

Image of the Day: Impaired Meiosis

Amy Schleunes | Feb 7, 2020

A phthalate commonly found in shampoos, cosmetics, and cleaning products disrupts reproduction in worms.

Image of the Day: Chromatin Forest

Emily Makowski | Jan 14, 2020

The DNA-protein complex has branches that fold back on themselves.

Infographic: Building an Artificial Chromosome

Ruth Williams | Nov 1, 2019

Integrating a specialized histone into large segments of transgenic DNA enables centromere formation.

Streamlined Artificial Chromosome Creation

Ruth Williams | Nov 1, 2019

Recruiting an epigenetic instigator of centromere formation into large segments of cloned DNA facilitates their transformation into artificial chromosomes.

Unbalanced Chromosomal Inheritance More Common than Thought

Jef Akst | Oct 11, 2019

A genomic analysis from 23andMe suggests that people inherit two copies of a chromosome from only one parent nearly twice as often as researchers had realized.