Discovering a new type of subnuclear body taught me how pursuing the unexpected can lead to new insights—in this case, about long noncoding RNAs and liquid-liquid phase separation in cells.

From regulating each other’s gene expression to encoding different parts of the same proteins, the two genome types in every eukaryotic cell are far from independent.

Interactions between mitochondrial and nuclear genomes have further-reaching effects on physiological function, adaptation, and speciation than previously appreciated.

Microscope-mounted magnets with computerized feedback control allow precision manipulations of intracellular objects.

Optimized tweezers enable precise 3-D manipulations of a cell’s organelles.

Zooming in on the ovarioles of Drosophila could reveal links between muscles, nutrition, and the development of eggs.

When lacking certain enzymes that help plants coordinate cell division, Arabidopsis thaliana cells grow and collect multiple nuclei.

The linkers gather chromosomes together into chromocenters.

Without certain DNA-binding proteins, chromosomes can escape the cell nucleus.

Researchers watch the protein condensin in action.

In the presence of cytosolic DNA, cancer cells activate antiviral pathways that disguise them as immune cells.

Errors in segregation during cell division can lead to inflammation in daughter cells.

Donald Coffey, a longtime professor at Johns Hopkins University, discovered the nuclear matrix within cells and its role in DNA replication.

A study provides the first visual evidence that cytofilaments tunnel through a cell’s nucleus to the extracellular matrix.

Solving a long-standing structural puzzle will open the door to understanding one of the cell’s most enigmatic machines.