STARmap reveals expression levels of multiple genes within thick tissue sections.
To visualize gene expression in a thick section of brain tissue with various cell types, RNA targets (top) are amplified to create multiple cDNA copies, each containing a barcode specific to the particular gene.
Acrylamide is then added to the tissue and cross-linked to the cDNA amplicons.
From the resulting hydrogel, fats and proteins are removed to leave a clear tissue within which the barcodes can be sequenced.
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Ruth is a freelance journalist. Before freelancing, Ruth was a news editor for the Journal of Cell Biology in New York and an assistant editor for Nature Reviews Neuroscience in London. Prior to that, she was a bona fide pipette-wielding, test tube–shaking, lab coat–shirking research scientist. She has a PhD in genetics from King’s College London, and was a postdoc in stem cell biology at Imperial College London. Today she lives and writes in Connecticut.
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