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A photo of a dish in which cells, which look like small dots, have been enlarged and stained to make them visible to the naked eye.
New Swelling Technique Makes Cells Visible to the Naked Eye
A new technique, called Unclearing Microscopy, physically inflates and then stains cells to circumvent the need for expensive microscopes.
New Swelling Technique Makes Cells Visible to the Naked Eye
New Swelling Technique Makes Cells Visible to the Naked Eye

A new technique, called Unclearing Microscopy, physically inflates and then stains cells to circumvent the need for expensive microscopes.

A new technique, called Unclearing Microscopy, physically inflates and then stains cells to circumvent the need for expensive microscopes.

techniques
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist Staff | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
woman entering MRI machine on platform
Researchers Report Decoding Thoughts from fMRI Data
Grace van Deelen | Oct 20, 2022 | 5 min read
A method appears to be the first to noninvasively reconstruct language from brain activity.
Fluorescence microscopy image of cells expressing fluorescent biosensors. Green and magenta fluorescence is observed outside of the cell nuclei.
Choosing Fluorescent Reagents for Every Live Cell Application
The Scientist’s Creative Services Team and MilliporeSigma | 4 min read
Scientists gain unique insights into active biological processes with specific fluorescent probes, dyes, and biosensors.
Images from a novel brain imaging technique, DIANA
New MRI Technique Tracks Brain Activity at Millisecond Timescales
Catherine Offord | Oct 14, 2022 | 4 min read
The method, dubbed “DIANA,” could transform neuroscientists’ understanding of how the brain works, researchers say—though for now, it’s only been tested in anesthetized mice.
Logo for The Scientist's 2022 Top 10 Innovations
Last Chance to Enter Our Annual Top 10 Innovations Contest
The Scientist Staff | Jul 11, 2022 | 1 min read
There is only one week remaining to submit your new product to vie for a coveted spot in The Scientist’s 2022 competition.
The Inside Scoop on Successful ATAC-seq Experiments
Technique Talk: The Inside Scoop on Successful ATAC-seq Experiments
The Scientist’s Creative Services Team | 1 min read
Discover how to best map a cell’s epigenetic landscape
Green-tinged image of fly eye with shiny and black portions
New CRISPR Technique Causes Few Unintended Mutations in Fruit Flies
Jason P. Dinh | Jul 1, 2022 | 4 min read
A study finds that CRISPR-Nickase, which changes just one allele of a given gene, improves gene editing efficiency compared with CRISPR-Cas9.
Conceptual image of blue neurons with glowing segments over blue background.
CRACK Method Reveals Novel Neuron Type in Mouse Brain
Dan Robitzski | Apr 18, 2022 | 3 min read
A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.
 Optimizing Protein Expression and Production
Technique Talk: Optimizing Protein Expression and Production
The Scientist’s Creative Services Team | 1 min read
Learn how to efficiently produce large quantities of a biologically active protein.
Illustration showing how calcium imaging and HCR-FISH combined is a technique called comprehensive readout of activity and cell type markers (CRACK)
Infographic: Simultaneously Studying Neuron Structure and Function
Dan Robitzski | Apr 18, 2022 | 1 min read
A new methodology combines existing techniques to reveal the specific function and location of multiple types of neurons at once.
colorful parrot-like bird riding a tiny bicycle on a tightrope
Reptiles are the Real Bird Brains
Sophie Fessl, PhD | Mar 22, 2022 | 4 min read
A research group argues that a species’ number of neurons, rather than brain volume, should serve as indicator of cognitive capacity when studying brain evolution, but some experts voice doubts.
800x560-thumbnail-sept-27
Technique Talk: Designing and Optimizing RNA-seq Experiments
The Scientist’s Creative Services Team | 1 min read
Learn how to select and perfect RNA-seq technologies to answer specific research questions.  
Histological stain of motor neurons in purple and green
Researchers Use Ultrasound to Control Neurons in Mice
Natalia Mesa, PhD | Feb 9, 2022 | 4 min read
A study shows “sonogenetics” could be a useful new tool in neuroscience and other fields.
illustration of a large purple molecular complex with a strand of orange RNA running through it and red strand emerging from it
Study Reveals Outsize Role of mRNA Region in Tuning Expression
Sophie Fessl, PhD | Jan 27, 2022 | 3 min read
A new method helps researchers uncover the rules of ribosome recruitment in yeast.
Modeling the Human Lung with Organoids
The Scientist Creative Services Team in collaboration with MilliporeSigma | 3 min read
A new specialized cell culture media system generates induced pluripotent stem cell-derived lung organoids that more closely resemble the diversity of cell types found in the human lung.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist Staff | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Isolated Realistic Coronavirus Covid-19 Molecule in a Biological Environment stock photo
Tweak to N Protein Makes Delta Variant More Infectious
Chloe Tenn | Nov 5, 2021 | 2 min read
Using a novel lab technique, researchers identified a mutation that allows the virus to insert more genetic material into host cells.
Simplifying Nucleic Acid Extraction and Cutting Down Waste
The Scientist Creative Services Team in collaboration with MilliporeSigma | 2 min read
A new approach to nucleic acid extraction efficiently frees RNA and DNA in just three steps, giving scientists back their precious time.
Rhino upside down, in the sky
2021 Ig Nobel Prizes Honor Decongestant Orgasms, Rhino Transport
Lisa Winter | Sep 14, 2021 | 2 min read
A full beard can absorb nearly 40 percent of the shock from a punch to the face, according to one winning study.
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