Conceptual image of blue neurons with glowing segments over blue background.
CRACK Method Reveals Novel Neuron Type in Mouse Brain
A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.
ABOVE: © istock.com, ismagilov
CRACK Method Reveals Novel Neuron Type in Mouse Brain
CRACK Method Reveals Novel Neuron Type in Mouse Brain

A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.

A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.

ABOVE: © istock.com, ismagilov

techniques

Illustration showing how calcium imaging and HCR-FISH combined is a technique called comprehensive readout of activity and cell type markers (CRACK)
Infographic: Simultaneously Studying Neuron Structure and Function
Dan Robitzski | Apr 18, 2022
A new methodology combines existing techniques to reveal the specific function and location of multiple types of neurons at once.
colorful parrot-like bird riding a tiny bicycle on a tightrope
Reptiles are the Real Bird Brains
Sophie Fessl | Mar 22, 2022
A research group argues that a species’ number of neurons, rather than brain volume, should serve as indicator of cognitive capacity when studying brain evolution, but some experts voice doubts.
The Inside Scoop on Successful ATAC-seq Experiments
Technique Talk: The Inside Scoop on Successful ATAC-seq Experiments
The Scientist Creative Services Team | Jan 17, 2022
Discover how to best map a cell’s epigenetic landscape
Histological stain of motor neurons in purple and green
Researchers Use Ultrasound to Control Neurons in Mice
Natalia Mesa | Feb 9, 2022
A study shows “sonogenetics” could be a useful new tool in neuroscience and other fields.
illustration of a large purple molecular complex with a strand of orange RNA running through it and red strand emerging from it
Study Reveals Outsize Role of mRNA Region in Tuning Expression
Sophie Fessl | Jan 27, 2022
A new method helps researchers uncover the rules of ribosome recruitment in yeast.
 Optimizing Protein Expression and Production
Technique Talk: Optimizing Protein Expression and Production
The Scientist Creative Services Team | Sep 2, 2021
Learn how to efficiently produce large quantities of a biologically active protein.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist Staff | Dec 1, 2021
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Isolated Realistic Coronavirus Covid-19 Molecule in a Biological Environment stock photo
Tweak to N Protein Makes Delta Variant More Infectious
Chloe Tenn | Nov 5, 2021
Using a novel lab technique, researchers identified a mutation that allows the virus to insert more genetic material into host cells.
800x560-thumbnail-sept-27
Technique Talk: Designing and Optimizing RNA-seq Experiments
The Scientist Creative Services Team | Aug 31, 2021
Learn how to select and perfect RNA-seq technologies to answer specific research questions.  
Rhino upside down, in the sky
2021 Ig Nobel Prizes Honor Decongestant Orgasms, Rhino Transport
Lisa Winter | Sep 14, 2021
A full beard can absorb nearly 40 percent of the shock from a punch to the face, according to one winning study.
One hand holds a white envelope with a blue and red striped border, while a second hand places a clear sheet of plastic inside with small squares of paper on it
Freeze-Dried Mouse Sperm Sent by Postcard Produces Baby Mice
Amanda Heidt | Aug 5, 2021
Rather than relying on samples that need to be shipped in glass vials and on ice, researchers have developed a new method that allows mouse sperm to be sent easily at room temperature using standard mail delivery.
Modeling the Human Lung with Organoids
The Scientist Creative Services Team in collaboration with MilliporeSigma | Mar 29, 2021
A new specialized cell culture media system generates induced pluripotent stem cell-derived lung organoids that more closely resemble the diversity of cell types found in the human lung.
Q8W3K0, listed in the DeepMind database as a potential plant disease resistance protein from Arabidopsis thaliana
Predictions of Most Human Protein Structures Made Freely Available
Lisa Winter | Jul 23, 2021
The AlphaFold program from AI firm DeepMind has amassed a huge database of protein structures from humans and model organisms.
Sodas, Lemon Juice Cause False Positives in Rapid COVID-19 Tests
Christie Wilcox | Jul 12, 2021
Lateral flow tests for COVID-19 can be very accurate and specific when used as directed, but introducing acidic fluids can cause the tests’ detecting antibodies to clump, which may read as a positive result.
Simplifying Nucleic Acid Extraction and Cutting Down Waste
The Scientist Creative Services Team in collaboration with MilliporeSigma | Mar 29, 2021
A new approach to nucleic acid extraction efficiently frees RNA and DNA in just three steps, giving scientists back their precious time.
corals in water with fish
First Immortal Cell Line Cultured for Reef-Building Corals
Amanda Heidt | Jul 1, 2021
Lab-grown cells from the reef-building coral Acropora tenuis provide new opportunities to study bleaching, symbioses, and biomineralization.
Infographic: How Scientists Are Creating Coral Cell Lines
Amanda Heidt | Jul 1, 2021
Stable, long-term cell lines will enable scientists to study everything from coral bleaching to biomineralization, knowledge that may help protect corals from ongoing climate change.
Technique Talk: Analyzing Molecular Interactions During Monoclonal Antibody Development
The Scientist Creative Services Team in collaboration with Sartorius Corporation | Mar 9, 2021
In this workshop, you will learn how to measure protein interactions using Octet bio-layer interferometry.
a white menstrual pad with pink and yellow spotting
Threads Embedded in Pads and Tampons Can Diagnose Yeast Infection
Emma Yasinski | Jun 15, 2021
The material turns bright pink when it comes in contact with an enzyme produced by the fungus Candida albicans.