How GFP-grabbing nanobodies enable instant tracking of protein dynamics in live cells.
LlamaTags (purple) grab cytoplasmic GFP (green), localizing it to the fused protein of interest (blue) and increasing GFP fluorescence intensity (top). In this example, the LlamaTagged protein is a transcription factor involved in patterning of the early fruit fly embryo. Recruitment of the readily available GFP to the tagged transcription factor therefore causes the nuclei containing the factor to glow brightly (bottom).
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Ruth is a freelance journalist. Before freelancing, Ruth was a news editor for the Journal of Cell Biology in New York and an assistant editor for Nature Reviews Neuroscience in London. Prior to that, she was a bona fide pipette-wielding, test tube–shaking, lab coat–shirking research scientist. She has a PhD in genetics from King’s College London, and was a postdoc in stem cell biology at Imperial College London. Today she lives and writes in Connecticut.
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These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".
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