Artist’s rendering of a neuron within a network.
| 3 min read
Jimmy Fong from Bruker discusses the latest technological advances for voltage imaging that help scientists unravel neuronal activity in the brain.

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Infographic showing how flow cytometry enables researchers to assess several cell parameters simultaneously at a single-cell level with the help of lasers.

Flow Cytometry: Scattering Light to Measure Cells

A cell with gold particles inside is hit with a red laser.

How Flow Cytometry Revolutionized Cell Biology Research

Discover How Automated Microscopy Streamlines Multiplexed Apoptosis Assays

Multiplexing Caspase-Based Apoptosis Assays with Automated Microscopy 

A scientist loads a 96-well plate containing qPCR reactions into a thermal cycler for DNA amplification and detection.

Insights into qPCR: Protocol, Detection Methods, and Analysis

Discover How CF® Dyes Let Scientists Delve Deeper into Biological Phenomena

CF® Dyes: Clearer Fluorescent Results

A multicolored illustration of a cell undergoing division.

See Beyond the Scatter Plot with Imaging, Spectral Flow Cytometry

Lipofuscin autofluorescence was quenched using EverBrite TrueBlack® Hardset Mounting Medium®, allowing effective visualization of glial cells (GFAP antibody stain, cyan) and cell nuclei (magenta) in human cerebral cortex cryosections.

Stepping Out of the Background

Illustration of newly discovered mechanism allowing kinesin to “walk” down a microtubule. A green kinesin molecule with an attached yellow fluorophore is shown passing through a blue laser as it rotates step by step along a red and purple microtubule, fueled by blue ATP molecules that are hydrolyzed into orange ADP and phosphate groups.

High-Resolution Microscope Watches Proteins Strut Their Stuff

Artist’s rendition of translucent teal proteins comprised of red spherical amino acids

Now AI Can Be Used to Design New Proteins

Fluorescence microscopy image of cells expressing fluorescent biosensors. Green and magenta fluorescence is observed outside of the cell nuclei.

Choosing Fluorescent Reagents for Every Live Cell Application

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Modernizing Drug Discovery with Flow Cytometry

To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

Infographic: DNA Damage Viewed with Unprecedented Clarity

Broken DNA

DNA Damage Viewed with Unprecedented Clarity

Learn About the Fundamental Principles and Protocols of Flow Cytometry

Streamlining Flow Cytometry Workflows with Best Practices

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Illuminating Fluorescent Experiments

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Illuminating Biology with Luminescence

Microscopic image of nerves in the eye, a pathogen, and t cells

Science Snapshot: Eye Immunity

Discover how flow cytometry accelerates drug screening

Adapting Flow Cytometry for Drug Discovery Workflows

An Improved Way to Detect CAR T Cells and SARS-CoV-2-Binding Cells

Technique Talk: An Improved Way to Detect CAR T Cells and SARS-CoV-2-Binding Cells

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Image of Atul Butte.

Biomedical Informatician Atul Butte Dies at 55

An illustration showing the accumulation of amyloid plaques between nerve cells, which is the underlying cause of disorders like Alzheimer’s and Parkinson’s disease.

A Gut Pathogen’s Unexpected Weapon Against Amyloid Diseases

Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

A group of newborn mice with their mother.

Maternal Iron Deficiency Can Trigger Sex Reversal in Mouse Embryos

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Conceptual 3D illustration of mycoplasma colonies

Taking Control of Cellular Contamination with PCR Testing

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Digital microscopy image of cells in culture

Electronic Records in Cell Culture Management

Image of small blue creatures called Nergals. Some have hearts above their heads, which signify friendship. There is one Nergal who is sneezing and losing health, which is denoted by minus one signs floating around it.
June 2025, Issue 1

Nergal Networks: Where Friendship Meets Infection

A citizen science game explores how social choices and networks can influence how an illness moves through a population.

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Unraveling Complex Biology with Advanced Multiomics Technology

Unraveling Complex Biology with Five-Dimensional Multiomics

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Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens

Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens

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Seeing and Sorting with Confidence

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Streamlining Microbial Quality Control Testing

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Products

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Agilent Unveils the Next Generation in LC-Mass Detection: The InfinityLab Pro iQ Series

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Pioneering Cancer Plasticity Atlas will help Predict Response to Cancer Therapies

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How Alderley Analytical are Delivering eXtreme Robustness in Bioanalysis