Artist’s rendering of a neuron within a network.
| 3 min read
Jimmy Fong from Bruker discusses the latest technological advances for voltage imaging that help scientists unravel neuronal activity in the brain.

fluorescence

Infographic showing how flow cytometry enables researchers to assess several cell parameters simultaneously at a single-cell level with the help of lasers.

Flow Cytometry: Scattering Light to Measure Cells

A cell with gold particles inside is hit with a red laser.

How Flow Cytometry Spurred Cell Biology

Discover How Automated Microscopy Streamlines Multiplexed Apoptosis Assays

Multiplexing Caspase-Based Apoptosis Assays with Automated Microscopy 

A scientist loads a 96-well plate containing qPCR reactions into a thermal cycler for DNA amplification and detection.

Insights into qPCR: Protocol, Detection Methods, and Analysis

Discover How CF® Dyes Let Scientists Delve Deeper into Biological Phenomena

CF® Dyes: Clearer Fluorescent Results

A multicolored illustration of a cell undergoing division.

See Beyond the Scatter Plot with Imaging, Spectral Flow Cytometry

Lipofuscin autofluorescence was quenched using EverBrite TrueBlack® Hardset Mounting Medium®, allowing effective visualization of glial cells (GFAP antibody stain, cyan) and cell nuclei (magenta) in human cerebral cortex cryosections.

Stepping Out of the Background

Illustration of newly discovered mechanism allowing kinesin to “walk” down a microtubule. A green kinesin molecule with an attached yellow fluorophore is shown passing through a blue laser as it rotates step by step along a red and purple microtubule, fueled by blue ATP molecules that are hydrolyzed into orange ADP and phosphate groups.

High-Resolution Microscope Watches Proteins Strut Their Stuff

Artist’s rendition of translucent teal proteins comprised of red spherical amino acids

Now AI Can Be Used to Design New Proteins

Fluorescence microscopy image of cells expressing fluorescent biosensors. Green and magenta fluorescence is observed outside of the cell nuclei.

Choosing Fluorescent Reagents for Every Live Cell Application

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Modernizing Drug Discovery with Flow Cytometry

To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

Infographic: DNA Damage Viewed with Unprecedented Clarity

Broken DNA

DNA Damage Viewed with Unprecedented Clarity

Learn About the Fundamental Principles and Protocols of Flow Cytometry

Streamlining Flow Cytometry Workflows with Best Practices

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Illuminating Fluorescent Experiments

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Illuminating Biology with Luminescence

Microscopic image of nerves in the eye, a pathogen, and t cells

Science Snapshot: Eye Immunity

Discover how flow cytometry accelerates drug screening

Adapting Flow Cytometry for Drug Discovery Workflows

An Improved Way to Detect CAR T Cells and SARS-CoV-2-Binding Cells

Technique Talk: An Improved Way to Detect CAR T Cells and SARS-CoV-2-Binding Cells

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Sex Determination: It’s in the Genes—Sometimes

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Olink® Reveal: Accessible NGS-based proteomics for every lab

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A researcher’s gloved hand holding a glass weighing boat with a loose powder sample on it

Minimizing to Maximize Measurement Accuracy

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A greyscale image of cells dividing.
March 2025, Issue 1

How Do Embryos Know How Fast to Develop

In mammals, intracellular clocks begin to tick within days of fertilization.

View this Issue
Discover the history, mechanics, and potential of PCR.

Become a PCR Pro

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3D rendered cross section of influenza viruses, showing surface proteins on the outside and single stranded RNA inside the virus

Genetic Insights Break Infectious Pathogen Barriers

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A photo of sample storage boxes in an ultra-low temperature freezer.

Navigating Cold Storage Solutions

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The Immunology of the Brain

The Immunology of the Brain

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Olink® Reveal: Accessible NGS-based proteomics for every lab

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Zymo Research Launches the Quick-16S™ Full-Length Library Prep Kit