Researchers repurpose the CRISPR machinery to turn whole classes of transposable elements on or off.
Investigate how transposons affect nearby genes, a vector containing 12 slightly different gRNAs targeted to a particular retroviral element is introduced into cells together with a Cas9-activator or -repressor fusion protein. The Cas9 protein associates with the gRNAs, and the subtle sequence differences of the gRNAs allow almost all copies of the targeted retroviral element to be switched on or off at once.
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Ruth is a freelance journalist. Before freelancing, Ruth was a news editor for the Journal of Cell Biology in New York and an assistant editor for Nature Reviews Neuroscience in London. Prior to that, she was a bona fide pipette-wielding, test tube–shaking, lab coat–shirking research scientist. She has a PhD in genetics from King’s College London, and was a postdoc in stem cell biology at Imperial College London. Today she lives and writes in Connecticut.
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Memory-enhancing neural networks may also drive involuntary musical loops in the brain.
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