Custom-designed kinases have built-in switches that act as gatekeepers for the enzymes' active sites.
© GEORGE RETSECK
Researchers have designed kinases that can be inactivated and activated by light. In violet light, engineered green fluorescent domains (called pdDronpa) dimerize, glow, and block the enzyme’s active site (top). In blue light, the domains break into monomers, lose their fluorescence, and uncage the kinase’s active site (bottom).
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