PhoreMost Ltd (PhoreMost), a biopharmaceutical company dedicated to drugging ‘undruggable’ disease targets, has entered into a research collaboration with the laboratory of Professor David Rubinsztein at the University of Cambridge. The groups will study and translate essential cellular mechanisms of neurodegenerative disorders into novel therapeutic strategies for diseases such as Parkinson’s and Alzheimer’s.
Professor Rubinsztein is Professor of Molecular Neurogenetics and Deputy Director of the Cambridge Institute for Medical Research. He also holds the appointment of Lead Academic Scientist of the Alzheimer’s Research UK Cambridge Drug Discovery Institute. Professor Rubinsztein’s laboratory is a world leader in cell autophagy, which is a natural pathway that monitors and degrades defective proteins in healthy cells. Therapeutic regulation of this pathway has the promise to reverse or prevent the deposition of aggregation-prone proteins in nerve cells that lead to neurodegenerative diseases.
Unfortunately, few druggable targets have yet been discovered that modulate the autophagy pathway. ...
