Today Lonza introduced the 4D-NucleofectorTM LV Unit to its transfection platforms. The new unit expands the proven 4D-Nucleofector™ System to closed, larger-scale transfection of up to 1x109 cells. Transfection protocols can be established in smaller scale using the 4D-Nucleofector™ X Unit and smoothly transferred to larger scale without the need for re-optimization. With this new addition, small- and large-scale transfection applications are now united in one system based on the highly efficient and established Nucleofector™ Technology.
Transfection is a powerful tool that is used to study and control gene expression by delivering DNA, RNA and even proteins into cells. Various applications within translational research require the generation of large numbers of transiently modified cell lines or primary cells. Such applications include modification of cells via genome editing or the generation of CAR-T cells for ex-vivo cell therapies, production of transient proteins or antibodies for construct screening, and generation of disease ...
