TO THE RESCUE: Upon liver injury, GATA6+ peritoneal macrophages sense ATP released from the wound and migrate toward it A. At the injury site, macrophage-liver interaction is mediated by binding of macrophages’ CD44 to the carbohydrate hyaluronan exposed on the injured tissue B. The macrophages degrade the nuclei of the dead hepatocytes and a layer of released DNA forms a cover across the wound C. © JULIA MOORE/MOOREILLUSTRATIONS.COMRead the full story.
Macrophages Respond to Liver Injury
In mice, immune cells from the body cavity surrounding organs arrive at the site of damage to chew up the nuclei of dead cells.
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