Artist’s rendition of multiple <em>Neisseria gonorrhoeae</em>, the bacteria that causes gonorrhea, depicted as two spheres stuck together, each covered in tendrils.
Gonorrhea-Blocking Mutation Also Protects Against Alzheimer’s: Study
Research traces the evolution of a gene variant that reduces the risk of Alzheimer’s disease, finding that it originally evolved in response to infectious bacteria.
Gonorrhea-Blocking Mutation Also Protects Against Alzheimer’s: Study
Gonorrhea-Blocking Mutation Also Protects Against Alzheimer’s: Study

Research traces the evolution of a gene variant that reduces the risk of Alzheimer’s disease, finding that it originally evolved in response to infectious bacteria.

Research traces the evolution of a gene variant that reduces the risk of Alzheimer’s disease, finding that it originally evolved in response to infectious bacteria.

macrophage
interstitium interstitial space cancer macrophage human anatomy
Cancer Cells Could Travel Through the Interstitium: Study
Marcus A. Banks | Apr 19, 2021
The continuous network of fluid-filled compartments crosses organ barriers and might serve as a conduit for tumor cells to spread.
neutrobots, neutrophils, white blood cells, microrobots, nanorobots, microbots, glioma, brain cancer, paclitaxel, magnetic, swarm, mice
Microscopic Robots Deliver Drugs to the Brain
Asher Jones | Mar 30, 2021
Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.
Salmonella living within macrophages can survive antibiotic treatment and potentially give rise to resistance by two different mechanisms that slow or arrest their growth.
Bacteria Go Dormant to Survive Antibiotics and Restart Infections
Niki Spahich, PhD
In Salmonella, two seemingly similar antibiotic survival strategies result from very different molecular mechanisms.
CAR Macrophages Tackle Challenges in Solid Cancer Treatment
Amanda Heidt | Mar 26, 2021
Following on the success of CAR T cells used to treat cancers of the blood, researchers have launched a Phase 1 clinical trial of genetically modified macrophages to target solid tumors.
Infographic: Envisioning Macrophages
Ashley Yeager | Mar 1, 2021
Researchers find different distributions of the immune cells in young, older, and diseased eyes.
Investigating the Immune Response Using Advanced Flow Cytometry
The Scientist Creative Services Team
Discover how researchers are using flow cytometry to delve into the inner workings of the immune life cycle!
Macrophages of the Human Eye Come into Focus
Ashley Yeager | Mar 1, 2021
Imaged in real time in living people, immune cells at the surface of the retina could serve as biomarkers to detect retinal and possibly neurological diseases and track their progression.
A Tweak to Immune Cells Reverses Aging in Mice
Abby Olena | Jan 20, 2021
Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.
bradykinin kinin cascade ras covid-19 sars-cov-2 dabk cytokines macrophage edema fluid lung leaky blood vessel
Is a Bradykinin Storm Brewing in COVID-19?
Alakananda Dasgupta | Aug 26, 2020
Excess of the inflammatory molecule bradykinin may explain the fluid build-up in the lungs of patients with coronavirus infections. Clinical trials of inhibitors are putting this hypothesis to the test.
bradykinin kinin cascade covid-19 sars-cov-2 coronavirus pandemic cytokine macrophage dabk ace2 ace immunology leaky blood vessel inflammation
Infographic: SARS-CoV-2 Interferes with Bradykinin Regulation
Alakananda Dasgupta | Aug 26, 2020
The leaky blood vessels and lung fluid build-up in some COVID-19 patients might be explained by the virus’s corruption of an inflammation safeguard.
bcg tuberculosis tb sars-cov-2 covid-19 coronavirus pandemic vaccine nonspecific effects trained immunity innate immune system response
An Old TB Vaccine Finds New Life in Coronavirus Trials
Anthony King | May 4, 2020
Studies are underway to test whether giving a shot of BCG vaccine could protect doctors and nurses against COVID-19.
Image of the Day: Brainless Frogs
Amy Schleunes | Feb 18, 2020
Without a brain, the frog embryo immune system doesn’t receive the signals it needs to mobilize macrophages and fight infections.
car t chimeric antigen receptor t cell immunotherapy pyroptosis cell death perforin macrophage leukemia lymphoma
Side Effect of CAR T Therapy Caused by Pyroptosis: Mouse Study
Kerry Grens | Jan 20, 2020
The immunotherapy induces a form of cell death in leukemia cells in mice that triggers cytokine release syndrome, a dangerous inflammatory reaction that occurs in some patients.
Mitochondria Play an Unexpected Role in Killing Bacteria
Katarina Zimmer | Jan 1, 2019
The energy-producing organelles also send out parcels with antimicrobial compounds to help destroy pathogen invaders in macrophages.
Macrophages Play a Double Role in Cancer
Amanda B. Keener | Apr 1, 2018
Macrophages play numerous roles within tumors, leaving cancer researchers with a choice: eliminate the cells or recruit them.
Hungry Macrophages Keep Tattoos on Mice’s Skin
Diana Kwon | Mar 7, 2018
A new study reveals that a constant stream of ink-gobbling immune cells helps hold tattoos in place.
Glial Ties to Persistent Pain
Mark R. Hutchinson | Jan 1, 2018
Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain.
Infographic: Two Pain Paths Diverge in the Body
Mark R. Hutchinson | Dec 31, 2017
The acute pain that results from injury or disease is very different from chronic pain.
Macrophages Are the Ultimate Multitaskers
Claire Asher | Oct 1, 2017
From guiding branching neurons in the developing brain to maintaining a healthy heartbeat, there seems to be no job that the immune cells can’t tackle.