July 2006

David Baker is professor of biochemistry and an HHMI investigator at the University of Washington. When he started there in 1994, the problem of "computing the structures of naturally occurring proteins and designing brand new ones [was] considered to be almost impossible," he says. His group has since created ROSETTA, a program that searches for lowest energy structures to do just this, and on page 34 he describes how it's being used to design an endonuclease to attack malaria

Being mindful of the extremes, science can remain a pursuit of reality.

The future of scientific meetings One of the very wonderful meeting formats, not mentioned in your story on the future of scientific meetings,1 was that of Kroc conferences, sponsored by the Kroc Foundation. The meetings allowed only 24 participants and met in the Double Arches Ranch near Solvang, California. There was a free-flowing bar, and ideal arrangements for continuing discussion between participants. The overall director of the meetings was Bob Kroc, Ray's brother

Credit: © ISTOCK.COMwww.ISTICK.COM" /> Credit: © ISTOCK.COMwww.ISTICK.COM When you're buying fish, you probably look at its color, smell it, and perhaps feel it for texture. If Martine Morzel has her way, you might also perform a mass spectrometry profile. Morzel, of the French National Institute for Agronomic Research, was interested in what effects preslaughter activity have on the quality of resulting fillets. In typical farming practice, trout kept in a large

AN ARCHAEAL PATHOGEN? X-ray from a necrotic tooth containing a periapical bone lesion Credit: COURTESY OF MORGANA ELI VIANNA" />AN ARCHAEAL PATHOGEN? X-ray from a necrotic tooth containing a periapical bone lesion Credit: COURTESY OF MORGANA ELI VIANNA The rogue's gallery of human pathogens is filled with members of the Bacteria and Eukaryota domains of life. Notably absent is the third domain: Archaea. According to a recent report in the Journal of Clinical Microbiology, however,

The last thing McGill University professor Brian Alters expected upon opening a letter late in March was to see his latest $40,000 Canadian ($36,400 US) grant rejected for not providing enough evidence to support a theory he'd made a career of defending: evolution. Alters had applied for funds from Canada's Social Sciences and Humanities Research Council (SSHRC) to study the effect of intelligent design debates in the United States on Canadian students, teachers, administrat

Credit: GETTY IMAGES" /> Credit: GETTY IMAGES It's a jungle out there on the Internet. With countless viruses, applets, and attachments on the loose, you might say that the systems designed to protect our computers are facing the kind of challenges that confront animal immune systems in a crowded environment. That's why Stephanie Forrest, a professor of computer science at the University of New Mexico, Albuquerque, calls this "computing in the wild." She argues that c

At Harvard, biology is an endangered species. Next fall's wide-eyed freshmen will have to head down the street to Massachusetts Institute of Technology if they want to concentrate (Harvard-speak for major) in the subject, because it will no longer be offered in Harvard Square. This change was puzzling to my editor, who concentrated in biology at Harvard, and to me, a 2005 graduate with a degree in biochemistry. So I consulted Robert Lue, my former advisor and cochair

Credit: © SCIENCE PHOTO LIBRARY" /> Credit: © SCIENCE PHOTO LIBRARY DOLLY TURNS 10 >> Had she lived, Dolly, the sheep cloned from an udder cell's nucleus, would have turned 10 on July 5. After Dolly: The Uses and Misuses of Human Cloning, by lead author on the 1997 announcement of Dolly's birth, Ian Wilmut and journalist Roger Highfield was released last month. BCG VACCINE TURNS 85 >> On July 18, 1921, Albert Calmette and Camille Guerin of the Pasteur Institut

Celebrating the woman who gave the world its first immortalized cell line

Ilya Shmulevich brings creative computation to deciphering gene regulation

A revolution aids the study of unculturable microorganisms

Ubiquitin does more than mark proteins for degradation. In 2004, Ingrid Wertz, a University of California, Davis graduate student, and advisor Vishva Dixit of Genentech, demonstrated that the protein A20, which was known to downregulate tumor necrosis factor á (TNFá) signaling, has both an ubiquitin ligase domain and a deubiquitinating domain.1 Wertz, now at the University of Washington, St. Louis, says she found the presence of these opposing functions disconcerting: "I was thinking, h

Credit: © MATTHEW ANTONINO" /> Credit: © MATTHEW ANTONINO Manufacturers use fluorinated organic chemicals in a variety of coatings on fabrics and paper plates and in fire-fighting foams. Now, these extremely stable compounds are showing up all over the globe. In 2004, Scott Mabury's group from the University of Toronto published a paper demonstrating perfluorinated contaminants in Canadian wildlife, from fish to fowl to fur, with highest concentrations at the top of the food chai

Credit: © YORGAS NIKAS/PHOTO RESEARCHERS" /> Credit: © YORGAS NIKAS/PHOTO RESEARCHERS Scientists once believed that human embryonic stem cells were extraordinarily stable in culture. In 2004, Peter Andrews at the University of Sheffield, UK, and colleagues revealed definitive evidence that lines can develop chromosomal abnormalities.1 Sheffield's group discovered three independent human embryonic stem cell lines that gained chromosome 17q on five independent occasions,

Cdk fashions

Pushing plasticity

I. Coppens et al.," Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space," Cell , 125:261-74, April 21, 2006. This outstanding paper shows that the intracellular protozoan Toxoplasma gondii exploits host microtubules to recruit and sequester host lysosomes into the parasitophorous vacuole. Through this process, the parasite gains access to host organelles that can provide a source of low-molecular-weight nu

Katherine Fitzgerald: Waiting, but not in vain

http://www.the-scientist.com/article/flash/23821/1/ Click to view enlarged diagram Credit: ILLUSTRATION: ANDREW MEEHAN" />http://www.the-scientist.com/article/flash/23821/1/ Click to view enlarged diagram Credit: ILLUSTRATION: ANDREW MEEHAN Invented in 1986 atomic force microscopy (AFM) has become a valuable tool for life scientists, offering the ability to image aqueous biological samples, like membranes, at nanometer resolution. The technique is akin to

Credit: COURTESY OF TERRY SHARRER (FLASK), GRETCHEN DARLINGTON (INSET)" /> Credit: COURTESY OF TERRY SHARRER (FLASK), GRETCHEN DARLINGTON (INSET) Growing cells outside the body began in 1907 with the work of Ross Harrison at the Johns Hopkins School of Medicine, and continued in the hands of Alexis Carrel and Montrose Burrows at the Rockefeller Institute. These investigators figured out the nutrient solutions that kept cells alive for extended periods of time and allowed them to