Contributors Peter Satir, a native New Yorker, became interested in ciliary motility when he saw protozoans swimming for the first time at Bronx High School of Science. Satir is currently a distinguished university professor at Albert Einstein College of Medicine in the anatomy and structural biology department, where he researches the mechanisms of primary cilia signaling, evolution of cilia, ciliogenesis, and nanotechnology using molecular motors. The questi
By Sarah Greene All the News That’s Fun to Print Scientific dialogue and that in the popular press can diverge radically. Why not explain that natural selection has already “engineered” the most invidious creatures imaginable? It’s a fun time to be a biologist. The Science paper from the J. Craig Venter Institute on reengineering a Mycoplasma cell using the techniques of synthetic biology stole the media spotlight for several wee
Mail Synthetic Bio, Meet “FBIo” If the FBI wants to help protect scientists from bioterrorism, strategy needs to be first on this list, not last. Unless the FBI understands that, they won’t get anywhere. Scientists will be justifiably reluctant to work with law enforcement until they can be assured that the policies and procedures that led to the Steve Kurtz persecution have been fundamentally changed. Any lab that messed up a
By Richard P. Grant Alphabet soup Why are we here? It’s a question that’s puzzled philosophers and scientists for centuries. “Every human society has its story of how everything began,” says William Martin, who studies evolution at the University of Düsseldorf. “Scientists do, too. It’s a fundamental human need. We want to know where we belong in the bigger picture.” One of the biggest unknowns is how th
One on One: Cell talk Martin Humphries on a paper that uses single-molecule techniques to resolve an important biological controversy. Cells bind to and communicate with the extracellular matrix via transmembrane integrins, enabling cells to respond to changes in their environment. To increase integrins’ affinity for ligand, the cell induces a process called “activation.” The details of how activation occurs, however, have been a mystery
Top 7 From F1000 Image by Tamily Weissman and Jean Livet / Harvard University 1. Mice have it licked » Imaging of many cortical neurons simultaneously in live mice maps crosstalk between specific neuron clusters, showing how brain circuits remodel while mice learn a task—in this case licking of water in response to different smells. T. Komiyama et al., Nature, 464:1182–86, 2010 Eval by Noam Ziv, Technion, Israel; Mark Mayford, Th
By H. Steven Wiley Scientists vs. Engineers One prefers the unknown, the other can’t stand it. Now more than ever, we have to find a way to get along. We are starting to get to a point where the engineering sciences can make a real impact on our progress. In the past, I have heard there was conflict between the “two cultures” of science and the humanities. I don’t see a lot of evidence for that type of conflict today, mostly because my
By Megan Scudellari BRAIN, INTERRUPTED It affects thousands per day, yet has no treatment, and receives only a small fraction of the funding allocated to much less common diseases. Now, researchers studying traumatic brain injury are making a last-ditch effort to transform the field. MedicalRF.com On a sunny Friday, postdoc Suzanne McKenna pulled into a left turn lane in Cary, NC, and stopped, waiting for the light to change. It was time to wrap up a few err
The Scientist Readers' Survey: Survey Questions Best Places to Work in Academia 2010 Category Question Job Satisfaction My work gives me great personal satisfaction. Job Satisfaction My research activities are valued by my colleagues. Job Satisfaction My teaching activities are valued by my students. Peers My peers are excellent scientists. Peers There is a high level of coop
The Scientist Readers' Survey: Methodology Best Places to Work in Academia 2010 Survey Form: A web-based survey form was posted on the web using Infopoll software from September 9, 2009 - March 8, 2010. Results were collected and collated automatically. Invitations: E-mail invitations were sent to readers of The Scientist and registrants on The Scientist web site who identified themselves as life scientists with a permanent position in an academic, hospital
By Richard Grant ATP: power and torque Courtesy of Daniela Stock The paper A.K. Lee et al., “The structure of the peripheral stalk of Thermus thermophilus H+-ATPase/synthase,” Nat Struct Mol Biol, 17:373–78, 2010. The finding Just like the turbines in a hydroelectric power plant, the revolving ‘turbine’ of the energy-generating ATPase requires a stationary component to counteract the rotation of proteins in the core. Daniela St
By Richard Grant Skin of heart Dr Boris Strilic / Lammert laboratory The paperB. Strilic et al., “The molecular basis of vascular lumen formation in the developing mouse aorta,” Dev Cell, 17:505–15, 2009. The findingEcki Lammert and colleagues at the University of Düsseldorf were looking to settle a debate: Do endothelial cells create blood vessels from expanding vacuoles, or do they flatten out and wrap into a hollow cylind
By Kelly Rae Chi Plant Matter Prowess Rooting out problems in biofuel production Plant matter is widely thought of as a promising alternative fuel source to petroleum. Of course, the key to unlocking lignocellulose—the main building block of plant cell walls and the most plentiful organic material on the planet—is to break down its hearty matrix of cellulose, hemicellulose, and lignin among others, and to do it as simply as possible. Turning pl
By Jef Akst Perry’s Arcana, 1810–1811 An architect by training, George Perry, Jr. from England was a self-proclaimed naturalist, publishing two largely graphical collections of the natural world—the Conchology, a large book that depicts shells of various species, and the Arcana, one of the first serial magazines of natural history. Each month, subscribers to the Arcana would receive a “little paper package” of loose-leaf pages—one to f
