October 1994

In 1993, the Food and Drug Administration (FDA) declined to approve Malvern, Pa.-based Centocor Inc.'s lead compound, Centoxin, sending the company into a near-fatal financial tailspin. Today, after a drastic retrenching, Centocor has recovered to be listed as one of the top 10 biotechnology firms by market valuation in the Ernst and Young report "Biotech '95: Reform, Restruc- ture, Renewal." A new angioplasty therapeutic called R

Scientists say launching Of the Hawaiian facilityis also a major step in restructuring of U.S.defense research efforts Scientists and government officials expect a recently launched United States Air Force supercomputer center in Hawaii--equipped with one of the world's most powerful parallel-processing computers, one of only two of its kind anywhere--to forge far-reaching collaborations among academic, industry, and government sc

Sidebar:Federal Research Funding Though many express general satisfaction with allocations, some observers warn of tough funding battles ahead The 1995 federal budget process has produced its traditional share of beneficiaries and victims, champions and critics. Some, for example, are heartened by a 14 percent funding increase for the National Science Foundation, while others view a modest budget raise for the National Institutes

In 1993, the Food and Drug Administration (FDA) declined to approve Malvern, Pa.-based Centocor Inc.'s lead compound, Centoxin, sending the company into a near-fatal financial tailspin. Today, after a drastic retrenching, Centocor has recovered to be listed as one of the top 10 biotechnology firms by market valuation in the Ernst and Young report "Biotech '95: Reform, Restruc- ture, Renewal." A new angioplasty therapeutic called R

Scientists say launching Of the Hawaiian facilityis also a major step in restructuring of U.S.defense research efforts Scientists and government officials expect a recently launched United States Air Force supercomputer center in Hawaii--equipped with one of the world's most powerful parallel-processing computers, one of only two of its kind anywhere--to forge far-reaching collaborations among academic, industry, and government sc

Sidebar:Federal Research Funding Though many express general satisfaction with allocations, some observers warn of tough funding battles ahead The 1995 federal budget process has produced its traditional share of beneficiaries and victims, champions and critics. Some, for example, are heartened by a 14 percent funding increase for the National Science Foundation, while others view a modest budget raise for the National Institutes

The program, called the Joint and Co-Sponsored U.N. Program on HIV/AIDS, was first proposed by the World Health Organization's (WHO) executive board of directors in January of this year. It was given final approval by the U.N. Economic and Social Council last month. Expected to be fully functional by January 1996, the program would link AIDS-related activities of six participating organizations: WHO; the World Bank; the U.N. Educati

The program, called the Joint and Co-Sponsored U.N. Program on HIV/AIDS, was first proposed by the World Health Organization's (WHO) executive board of directors in January of this year. It was given final approval by the U.N. Economic and Social Council last month. Expected to be fully functional by January 1996, the program would link AIDS-related activities of six participating organizations: WHO; the World Bank; the U.N. Educati

President Clinton's choices for the winners of the 1994-95 Enrico Fermi Award--Freeman Dyson, a professor, emeritus, of physics at the Institute for Advanced Study in Princeton, N.J., and Liane B. Russell, a geneticist who is a senior corporate fellow at the Oak Ridge National Laboratory in Tennessee--reflect a changing attitude on the part of the United States government about the benefits of nuclear power, say some scientists. Th

President Clinton's choices for the winners of the 1994-95 Enrico Fermi Award--Freeman Dyson, a professor, emeritus, of physics at the Institute for Advanced Study in Princeton, N.J., and Liane B. Russell, a geneticist who is a senior corporate fellow at the Oak Ridge National Laboratory in Tennessee--reflect a changing attitude on the part of the United States government about the benefits of nuclear power, say some scientists. Th

Department of Energy -Energy supply R&D 3,224 3,424 3,315 -Gen. Sci & Res. 1,615 1,074 984 National Aeronautics and Space Administration --Space station R&D 1,940 1,890 1,890 --Science, aeronautics, 5,788 5,901 5,901 and technology National Institute of Standards and Technology 520 935 855 Environmental Protection Agency (R&D) 338 364 350 National Oceanic and Atmospheric Administration 227 238 259 Department of

Department of Energy -Energy supply R&D 3,224 3,424 3,315 -Gen. Sci & Res. 1,615 1,074 984 National Aeronautics and Space Administration --Space station R&D 1,940 1,890 1,890 --Science, aeronautics, 5,788 5,901 5,901 and technology National Institute of Standards and Technology 520 935 855 Environmental Protection Agency (R&D) 338 364 350 National Oceanic and Atmospheric Administration 227 238 259 Department of

David M. Goldenberg, president of the Garden State Cancer Center, a cancer research institution in Newark, N.J., and Jean-Pierre Mach, a professor of biochemistry in the faculty of medicine at Lausanne University, Switzerland--were honored last month with the 1994 Abbott Award. The award was presented at the 22nd meeting of the International Society for Oncodevelopmental Biology (ISOBM), held in Groningen, the Netherlands. ISOBM, cu

David M. Goldenberg, president of the Garden State Cancer Center, a cancer research institution in Newark, N.J., and Jean-Pierre Mach, a professor of biochemistry in the faculty of medicine at Lausanne University, Switzerland--were honored last month with the 1994 Abbott Award. The award was presented at the 22nd meeting of the International Society for Oncodevelopmental Biology (ISOBM), held in Groningen, the Netherlands. ISOBM, cu

The World Health Organization (WHO), based in Geneva, will back large-scale clinical trials of two experimental HIV vaccines that failed earlier this year to win similar approval in the United States. In June, Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID), chose not to support the complex and costly trials because "the science wasn't there to justify it." Each vaccine relies on stimul

The World Health Organization (WHO), based in Geneva, will back large-scale clinical trials of two experimental HIV vaccines that failed earlier this year to win similar approval in the United States. In June, Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID), chose not to support the complex and costly trials because "the science wasn't there to justify it." Each vaccine relies on stimul

Confidence and ambition, however, are ceding to worry and resignation. We see increasing numbers of our comrades getting stuck in perpetual postdoctoral appointments while they apply over and over for rare faculty jobs. Even if one attains a cherished tenure-track position, the chances of earning a competitive research grant have seldom been worse. The situation is clearly discouraging, since fewer and fewer biomedical faculty under

Confidence and ambition, however, are ceding to worry and resignation. We see increasing numbers of our comrades getting stuck in perpetual postdoctoral appointments while they apply over and over for rare faculty jobs. Even if one attains a cherished tenure-track position, the chances of earning a competitive research grant have seldom been worse. The situation is clearly discouraging, since fewer and fewer biomedical faculty under

The Scientist, page 13] and its support for the recent consensus statement urging federal funding increases for biomedical research. Equally appealing is the suggestion for developing arguments for research support based upon scientists' own case histories of research experience. It is not only reduced funding, however, that threatens the future of biomedical research, but also the chilling effect of continued negative public relati

Your point/counterpoint on "The Use Of Animals In Laboratory Research" (K.P. Stoller, S.E. Paris, The Scientist, Sept. 5, 1994, page 12) was subtitled "Debate Presses Forward," but "Debate Fails to Materialize" would have been more appropriate. Susan Paris ("Animal Rights Advocates' Actions Pose Big Threat To Public Health") ignores Kenneth Stoller's ethical and technical critique of animal modeling ("Experimentation On Animals Reta

Your point/counterpoint on "The Use Of Animals In Laboratory Research" (K.P. Stoller, S.E. Paris, The Scientist, Sept. 5, 1994, page 12) was subtitled "Debate Presses Forward," but "Debate Fails to Materialize" would have been more appropriate. Susan Paris ("Animal Rights Advocates' Actions Pose Big Threat To Public Health") ignores Kenneth Stoller's ethical and technical critique of animal modeling ("Experimentation On Animals Reta

The Scientist, page 13] and its support for the recent consensus statement urging federal funding increases for biomedical research. Equally appealing is the suggestion for developing arguments for research support based upon scientists' own case histories of research experience. It is not only reduced funding, however, that threatens the future of biomedical research, but also the chilling effect of continued negative public relati

The project unearthed a vast array of successful efforts throughout the United States to connect African American, Latino, and American Indian students with science and engineering. A subsequent project concentrated on successful efforts to do the same for girls and women. In general, my colleagues and I discovered, these efforts--or "interventions"--had been developed to ensure that at least a few people from underrepresented group

The project unearthed a vast array of successful efforts throughout the United States to connect African American, Latino, and American Indian students with science and engineering. A subsequent project concentrated on successful efforts to do the same for girls and women. In general, my colleagues and I discovered, these efforts--or "interventions"--had been developed to ensure that at least a few people from underrepresented group

Sidebar:The Most-Cited Chemistry Papers of 1991-93 chemistry papers published from 1991 to 1993 and reported in the July/August 1994 issue of the newsletter Science Watch, articles on fullerenes and related molecules still are among the most cited in the field. The dominance of fullerenes aside, several other areas of chemistry are also on the move: asymmetric synthesis, surface chemistry, computational chemistry, macromolecular str

Sidebar:The Most-Cited Chemistry Papers of 1991-93 chemistry papers published from 1991 to 1993 and reported in the July/August 1994 issue of the newsletter Science Watch, articles on fullerenes and related molecules still are among the most cited in the field. The dominance of fullerenes aside, several other areas of chemistry are also on the move: asymmetric synthesis, surface chemistry, computational chemistry, macromolecular str

Reprinted from Science Watch, pp.15 Date: October 31, 1994 Back To: So Far, Fullerene Studies Dominate Chemical Citations In The 1990s Source:ISI's Science Indicators Database, 1991-93 Rank1991Total No. of Citations 1P.J. Kraulis, "Molscript: a program to produce both detailed and schematic plots of protein structures," Journal of Applied Crystallography, 24:946-50, 1991. [Uppsala University, Sweden] 280 2R.C. Haddon, A.F. Hebard

Reprinted from Science Watch, pp.15 Date: October 31, 1994 Back To: So Far, Fullerene Studies Dominate Chemical Citations In The 1990s Source:ISI's Science Indicators Database, 1991-93 Rank1991Total No. of Citations 1P.J. Kraulis, "Molscript: a program to produce both detailed and schematic plots of protein structures," Journal of Applied Crystallography, 24:946-50, 1991. [Uppsala University, Sweden] 280 2R.C. Haddon, A.F. Hebard

A.F.M. Smith, G.O. Roberts, "Bayesian computation via the Gibbs sampler and related Markov-Chain Monte-Carlo methods," Journal of the Royal Statistical Society Series B, 55:3-23, 1993. Gareth Roberts (Statistical Laboratory, University of Cambridge, England): "The Markov-Chain Monte-Carlo (MCMC) methodology has been around for more than 40 years. However, until recently, its applications have been largely confined to statistical p

J. Gao, X. Xia, "A priori evaluation of aqueouspolarization effects through Monte-Carlo QM-MMsimulations," Science, 258:631-5, 1992. Jiali Gao (Department of Chemistry, State University of New York, Buffalo): "Monte Carlo and molecular dynamics simulations of such biological macromolecules as proteins and nucleic acids in aqueous solution can provide a detailed understanding of their structure, function, and dynamics. One of the c

K. Burridge, C.E. Turner, L.H. Romer, "Tyrosine phos-phorylation of paxillin and pp125fak accompanies cell adhesion to extracellular matrix: A role in cytoskeletal assembly," Journal of Cell Biology, 119:893-903, 1992. Keith Burridge (Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill): "The extracellular matrix (ECM) influences the growth, differentiation, motility, and morphologyof cells. In culture

A.F.M. Smith, G.O. Roberts, "Bayesian computation via the Gibbs sampler and related Markov-Chain Monte-Carlo methods," Journal of the Royal Statistical Society Series B, 55:3-23, 1993. Gareth Roberts (Statistical Laboratory, University of Cambridge, England): "The Markov-Chain Monte-Carlo (MCMC) methodology has been around for more than 40 years. However, until recently, its applications have been largely confined to statistical p

J. Gao, X. Xia, "A priori evaluation of aqueouspolarization effects through Monte-Carlo QM-MMsimulations," Science, 258:631-5, 1992. Jiali Gao (Department of Chemistry, State University of New York, Buffalo): "Monte Carlo and molecular dynamics simulations of such biological macromolecules as proteins and nucleic acids in aqueous solution can provide a detailed understanding of their structure, function, and dynamics. One of the c

K. Burridge, C.E. Turner, L.H. Romer, "Tyrosine phos-phorylation of paxillin and pp125fak accompanies cell adhesion to extracellular matrix: A role in cytoskeletal assembly," Journal of Cell Biology, 119:893-903, 1992. Keith Burridge (Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill): "The extracellular matrix (ECM) influences the growth, differentiation, motility, and morphologyof cells. In culture

"We are trying to make a statistics program that everyone can use, and Windows, in particular, is helping us do that," says Paul Portrey, assistant manager of technical support at Stat-Soft Inc. in Tulsa, Okla. "If developers take advantage of the features of Windows, they can make a package that's very easy to work with." Windows is not an operating system but an add-on to the DOS operating system that drives IBM and compatible PCs

"We are trying to make a statistics program that everyone can use, and Windows, in particular, is helping us do that," says Paul Portrey, assistant manager of technical support at Stat-Soft Inc. in Tulsa, Okla. "If developers take advantage of the features of Windows, they can make a package that's very easy to work with." Windows is not an operating system but an add-on to the DOS operating system that drives IBM and compatible PCs

Spreadsheet National Instruments Offers Updated Versions of LabVIEW Graphical Instrumentation Software Molecular Dynamics' Stand-Alone Confocal Software Antigenix Provides Human VCAM Antibody Reagent Hamamatsu Introduces Series of Photomultiplier Tubes Protein Analysis Kits For Capillary Electrophoresis Analtech Unveils Sample Application Device For TLC Bibliographic Data Software From PBS Spreadsheet Software Package The DADiSP gra

Spreadsheet National Instruments Offers Updated Versions of LabVIEW Graphical Instrumentation Software Molecular Dynamics' Stand-Alone Confocal Software Antigenix Provides Human VCAM Antibody Reagent Hamamatsu Introduces Series of Photomultiplier Tubes Protein Analysis Kits For Capillary Electrophoresis Analtech Unveils Sample Application Device For TLC Bibliographic Data Software From PBS Spreadsheet Software Package The DADiSP gra

The Mattia award was established in 1972 by Hoffmann La-Roche Inc. in honor of V.D. Mattia, who served as president and CEO of the company from 1965 to 1971 and was instrumental in setting up the molecular biology institute. Nine of the 25 winners to date have gone on to receive the Nobel Prize, the most recent being 1989 chemistry Nobelist Thomas Cech of the University of Colorado, Boulder, who received the Mattia award in 1987. R

The Mattia award was established in 1972 by Hoffmann La-Roche Inc. in honor of V.D. Mattia, who served as president and CEO of the company from 1965 to 1971 and was instrumental in setting up the molecular biology institute. Nine of the 25 winners to date have gone on to receive the Nobel Prize, the most recent being 1989 chemistry Nobelist Thomas Cech of the University of Colorado, Boulder, who received the Mattia award in 1987. R