Mind-Controlled Gene Expression

A light-inducible optogenetic implant in mice, powered by EEG, responds to a human participant’s mental state.

| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

WIKIPEDIA, RAMAThoughts have power—sort of. A new device uses the electric energy of a person’s brainwaves to trigger a light-emitting diode, which then remotely activates light-inducible genes in a small implant placed in mice.

The system, described in Nature Communications today (November 11), may eventually provide new gene and cell-based treatment opportunities that respond to an individual’s specific mental states. Although the contraption sounds unusual, it relies on combining two well-known technologies: optogenetics, which uses light-sensitive proteins to control gene expression, and an EEG-based brain-computer interface (BCI), which harnesses the brain’s electrical potentials to create a physical output.

“This work is pretty awesome,” said synthetic biologist Timothy Lu of MIT who was not involved with the study. “This is the first time people have gone this far with combining these technologies.”

Martin Fussenegger of ETH Zurich, who led the new research, has been working on ways to remotely control gene expression for nearly a decade. His recent work has ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • Jyoti Madhusoodanan

    This person does not yet have a bio.
Share
A greyscale image of cells dividing.
March 2025, Issue 1

How Do Embryos Know How Fast to Develop

In mammals, intracellular clocks begin to tick within days of fertilization.

View this Issue
Discover the history, mechanics, and potential of PCR.

Become a PCR Pro

Integra Logo
3D rendered cross section of influenza viruses, showing surface proteins on the outside and single stranded RNA inside the virus

Genetic Insights Break Infectious Pathogen Barriers

Thermo Fisher Logo
A photo of sample storage boxes in an ultra-low temperature freezer.

Navigating Cold Storage Solutions

PHCbi logo 
The Immunology of the Brain

The Immunology of the Brain

Products

Sapio Sciences

Sapio Sciences Makes AI-Native Drug Discovery Seamless with NVIDIA BioNeMo

DeNovix Logo

New DeNovix Helium Nano Volume Spectrophotometer

Olink Logo

Olink® Reveal: Accessible NGS-based proteomics for every lab

Olink logo
Zymo Logo

Zymo Research Launches the Quick-16S™ Full-Length Library Prep Kit