BELLSHILL, SCOTLAND, 26 March 2014: Link Technologies Ltd (www.linktech.co.uk), an ISO 9001:2008 certified specialist oligonucleotide reagent manufacturer, has expanded its range of lipophilic modifiers for the effective delivery of oligonucleotides into cells. As oligos continue to be of interest in drug discovery, offering exciting potential as therapeutic agents, there is an increasing demand for improved oligo delivery techniques. Link’s proven collection of lipophilic oligo modification reagents, which include cholesterol and tocopherol modifiers, now also includes 5’-Palmitate-C6-CE Phosphoramidite. As a derivative of palmitic acid, a physiologically common fatty acid, the new palmitate modifier is the first palmitate phosphoramidite available commercially, and provides scientists with an ideal approach to improve the cellular uptake and utilisation of oligos.
In the cell, palmitic acid is known to conjugate to proteins via cysteine residues and, in doing so, is believed to aid the movement of proteins between intracellular compartments. It is also known that improved ...
