Which Neurons Go to Sleep First in Humans? fMRI Can Tell

By linking blood flow patterns to bioelectric signals in the brains of sleeping volunteers, scientists are studying the order in which brain regions fall asleep and wake up.

Written byAlejandra Manjarrez, PhD
| 3 min read
Artistic representation of a brain depicted as a clock on a background with one half in dark blue with yellow stars and one half in light blue with clouds.
Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

In the last decades, science has taught us that the mammalian brain isn’t always entirely awake or asleep. Dolphins can swim with one hemisphere asleep while the other is alert, and some neurons in sleep-deprived rats can “switch off” while the animals are still awake. In humans, this so-called “local sleep,” in which specific neuronal populations take a nap while the rest of the brain is awake, has been more challenging to study, since the invasive methods used to track it in other mammals cannot be used on people.

A new study published July 21 in PNAS seems to have overcome this challenge. By simultaneously mapping human brain signals measured with two different methods (one with good temporal resolution and the other with good spatial resolution), the team pinpointed the waking or sleeping state of neuronal populations at the local level. The achievement made it possible to identify which brain ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • alejandra manjarrez

    Alejandra Manjarrez is a freelance science journalist who contributes to The Scientist. She has a PhD in systems biology from ETH Zurich and a master’s in molecular biology from Utrecht University. After years studying bacteria in a lab, she now spends most of her days reading, writing, and hunting science stories, either while traveling or visiting random libraries around the world. Her work has also appeared in Hakai, The Atlantic, and Lab Times.

    View Full Profile
Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina

Products

nuclera logo

Nuclera eProtein Discovery System installed at leading Universities in Taiwan

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo