Opinion: An Alternative to Injection

Research on microneedle patches for vaccine delivery has grown in popularity in recent years, due to their exceptional compliance and low invasiveness.

| 3 min read
A microneedle patch on a fingertip

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ABOVE: COURTESY OF CARMINE D’AMICO

Over the past 18 months, the world has been amazed at how fast scientists can develop vaccine candidates against COVID-19. The majority of these vaccinations are administered via hypodermic injection, which allows the vaccine’s ingredients to be swiftly assimilated into the bloodstream. However, some require multiple doses, and most must be kept at controlled, often super-cold temperatures until they can be administered by trained personnel, creating major logistical challenges.

Several researchers, including ourselves, are working on a technology that aims to provide the advantages of injectable vaccines without the drawbacks—and without the traditional needle stick: microneedles. While the technology still has a long road to the clinic, having entered human trials less than 10 years ago, we believe this it is the future of vaccine delivery, and the ongoing pandemic has highlighted the need to accelerate its development.

Basically, an array of tiny needles measuring ...

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Meet the Author

  • Headshot of Hélder Santos

    Hélder Santos

    Hélder Santos is a research director at the Faculty of Pharmacy of the University of Helsinki in Finland, head of the Department of Biomedical Engineering at the University Medical Center Groningen in The Netherlands, and the leading principal investigator on a large microneedle technology project funded by the Business Finland.

  • Headshot of Carmine D’Amico

    Carmine D’Amico

    Carmine D’Amico is a doctoral student in the lab of Hélder Santos at the Faculty of Pharmacy of the University of Helsinki in Finland exploring microneedles technology for drug delivery and encapsulation of nanoparticles.

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