Questions Raised About Widely Used Blood-Brain Barrier Model
Questions Raised About Widely Used Blood-Brain Barrier Model
A study has sparked controversy by suggesting that cells made using a popular lab protocol have been misidentified, with potentially serious repercussions for brain research. Critics say the significance of the findings has been overstated.
Questions Raised About Widely Used Blood-Brain Barrier Model
Questions Raised About Widely Used Blood-Brain Barrier Model

A study has sparked controversy by suggesting that cells made using a popular lab protocol have been misidentified, with potentially serious repercussions for brain research. Critics say the significance of the findings has been overstated.

A study has sparked controversy by suggesting that cells made using a popular lab protocol have been misidentified, with potentially serious repercussions for brain research. Critics say the significance of the findings has been overstated.

drug delivery
Infographic: Building Bacteria to Fight Cancer
Infographic: Building Bacteria to Fight Cancer
Simone Schuerle, Tal Danino | Apr 1, 2020
Researchers are engineering microbes to deliver therapeutics specifically to tumors, maximizing the treatments’ efficacy while minimizing side effects.
Bacteria as Living Microrobots to Fight Cancer
Bacteria as Living Microrobots to Fight Cancer
Simone Schuerle, Tal Danino | Apr 1, 2020
Autonomous, living microrobots that seek and destroy cancer are not as futuristic as one might imagine, thanks to a fusion of robotics and synthetic biology.
Laser-Triggered Nanobubbles Blast a Path into Biofilms
Laser-Triggered Nanobubbles Blast a Path into Biofilms
Jonathan Wosen | Apr 1, 2020
Researchers could one day use the method to deliver antibiotics to topical wounds infected by hard-to-treat masses of bacteria.
CRISPR-Based Tool Expands DNA-Hydrogel Versatility
CRISPR-Based Tool Expands DNA-Hydrogel Versatility
Ruth Williams | Dec 1, 2019
DNA-responsive polymer gels used for releasing drugs, encapsulating cells, and much more now have greater adaptability thanks to the Cas12a nuclease.
Trial of Gene Therapy for Duchenne Muscular Dystrophy Put on Hold
Trial of Gene Therapy for Duchenne Muscular Dystrophy Put on Hold
Catherine Offord | Nov 12, 2019
The US Food and Drug Administration halts a study by Solid Biosciences after a patient experiences severe side effects following treatment.
Image of the Day: Smartphone-Controlled Brains
Image of the Day: Smartphone-Controlled Brains
Nicoletta Lanese | Aug 7, 2019
A device implanted into mice can modulate brain circuit activity over long periods of time.
Image of the Day: Artificial Snake Bite
Image of the Day: Artificial Snake Bite
Nicoletta Lanese | Aug 6, 2019
A microneedle delivers liquid medicines through tiny, fang-like points.
Image of the Day: Right on Target
Image of the Day: Right on Target
Nicoletta Lanese | Jul 23, 2019
An injectable biomaterial calls cancer drugs to tumor sites in mice.
World’s Largest Cell and Gene Therapy Plant Opens
World’s Largest Cell and Gene Therapy Plant Opens
Catherine Offord | Apr 10, 2018
Lonza will employ more than 200 full-time staff to work at the Texas-based facility, the company says.
Researchers Develop Sperm-Robot Hybrids to Deliver Drugs, Assist Fertilization
Researchers Develop Sperm-Robot Hybrids to Deliver Drugs, Assist Fertilization
Diana Kwon | Apr 1, 2018
The artificially motorized cells may one day help fight cancers in the female reproductive tract.
Getting Drugs Past the Blood-Brain Barrier
Getting Drugs Past the Blood-Brain Barrier
Amanda B. Keener | Nov 1, 2017
To treat neurological disease, researchers develop techniques to bypass or trick the guardian of the central nervous system.
Infographic: Breaking into the Brain
Infographic: Breaking into the Brain
Amanda B. Keener | Oct 31, 2017
The blood-brain barrier is a collection of specialized cells and proteins that control the movement of molecules from the blood to the central nervous system.
DNA-Delivered Antibodies Fight Off Lethal Bacterial Infection
DNA-Delivered Antibodies Fight Off Lethal Bacterial Infection
Catherine Offord | Oct 3, 2017
Mice receiving the treatment produced their own monoclonal antibodies and survived infection with the life-threatening pathogen Pseudomonas aeruginosa.
Tiny Motors Deliver Ulcer Medication in Mouse Stomachs
Tiny Motors Deliver Ulcer Medication in Mouse Stomachs
Shawna Williams | Aug 16, 2017
The mini machines treated infection somewhat better than antibiotics plus the typical proton pump inhibitor medication. 
Image of the Day: Teeny Tiny Delivery Balls
Image of the Day: Teeny Tiny Delivery Balls
The Scientist Staff | Aug 3, 2017
Scientists designed autonomous nanovesicles capable of following glucose concentration gradients, even through the blood brain barrier in rats.
Making Micromotors Biocompatible
Making Micromotors Biocompatible
Jyoti Madhusoodanan | Jun 1, 2016
Researchers are developing potent ways to fuel and control the movement of micromotor devices.
Tumor-Shrinking Triple-Helices
Tumor-Shrinking Triple-Helices
Ruth Williams | Apr 1, 2016
A braided structure and some adhesive hydrogel make therapeutic microRNAs both stable and sticky.
Dying Light Marks the Spot
Dying Light Marks the Spot
Catherine Offord | Mar 28, 2016
Drug-delivering nanoparticles designed to glow when their target cells die can report on the effectiveness of cancer therapies within just a few hours of treatment, a mouse study shows.
Bacterial Taxis Deliver Proteins
Bacterial Taxis Deliver Proteins
Kerry Grens | Apr 28, 2015
Reengineered protein-shuttling machinery can be used to inject a particular protein into mammalian cells, according to a proof-of-principle study.