A microneedle patch on a fingertip
Opinion: An Alternative to Injection
Research on microneedle patches for vaccine delivery has grown in popularity in recent years, due to their exceptional compliance and low invasiveness.
ABOVE: Courtesy of Carmine D’Amico
Opinion: An Alternative to Injection
Opinion: An Alternative to Injection

Research on microneedle patches for vaccine delivery has grown in popularity in recent years, due to their exceptional compliance and low invasiveness.

Research on microneedle patches for vaccine delivery has grown in popularity in recent years, due to their exceptional compliance and low invasiveness.

ABOVE: Courtesy of Carmine D’Amico

drug delivery

Red blood vessels that decrease in diameter as they radiate outward are pictured on a pink and white surface
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Abby Olena | Aug 18, 2021
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
Questions Raised About Widely Used Blood-Brain Barrier Model
Catherine Offord | Feb 16, 2021
A study has sparked controversy by suggesting that cells made using a popular lab protocol have been misidentified, with potentially serious repercussions for brain research. Critics say the significance of the findings has been overstated.
Linking Biological Clocks and Cancer Therapeutics to Minimize Toxicity
It’s All in the Timing: Optimizing Chemotherapy Administration
Sejal Davla, PhD | Mar 1, 2022
How the biological clock influences chemotherapy success
Infographic: Building Bacteria to Fight Cancer
Simone Schuerle, Tal Danino | Apr 1, 2020
Researchers are engineering microbes to deliver therapeutics specifically to tumors, maximizing the treatments’ efficacy while minimizing side effects.
Bacteria as Living Microrobots to Fight Cancer
Simone Schuerle, Tal Danino | Apr 1, 2020
Autonomous, living microrobots that seek and destroy cancer are not as futuristic as one might imagine, thanks to a fusion of robotics and synthetic biology.
Harnessing microRNAs for Cancer Therapeutics
Harnessing microRNAs for Cancer Therapeutics
The Scientist Creative Services Team | Jan 12, 2022
Andrea Kasinski and Masako Harada will discuss the role of microRNAs in cancer, as well as the potential and challenges of using microRNAs for cancer therapeutics.
Laser-Triggered Nanobubbles Blast a Path into Biofilms
Jonathan Wosen | Apr 1, 2020
Researchers could one day use the method to deliver antibiotics to topical wounds infected by hard-to-treat masses of bacteria.
CRISPR-Based Tool Expands DNA-Hydrogel Versatility
Ruth Williams | Dec 1, 2019
DNA-responsive polymer gels used for releasing drugs, encapsulating cells, and much more now have greater adaptability thanks to the Cas12a nuclease.
Trial of Gene Therapy for Duchenne Muscular Dystrophy Put on Hold
Catherine Offord | Nov 12, 2019
The US Food and Drug Administration halts a study by Solid Biosciences after a patient experiences severe side effects following treatment.
smartphone controlled device implanted in mouse brain
Image of the Day: Smartphone-Controlled Brains
Nicoletta Lanese | Aug 7, 2019
A device implanted into mice can modulate brain circuit activity over long periods of time.
Microneedle patch delivers liquid medications
Image of the Day: Artificial Snake Bite
Nicoletta Lanese | Aug 6, 2019
A microneedle delivers liquid medicines through tiny, fang-like points.
Hydrogel injected near tumors help recruit cancer drugs to the site
Image of the Day: Right on Target
Nicoletta Lanese | Jul 23, 2019
An injectable biomaterial calls cancer drugs to tumor sites in mice.
World’s Largest Cell and Gene Therapy Plant Opens
Catherine Offord | Apr 10, 2018
Lonza will employ more than 200 full-time staff to work at the Texas-based facility, the company says.
Researchers Develop Sperm-Robot Hybrids to Deliver Drugs, Assist Fertilization
Diana Kwon | Apr 1, 2018
The artificially motorized cells may one day help fight cancers in the female reproductive tract.
Getting Drugs Past the Blood-Brain Barrier
Amanda B. Keener | Nov 1, 2017
To treat neurological disease, researchers develop techniques to bypass or trick the guardian of the central nervous system.
Infographic: Breaking into the Brain
Amanda B. Keener | Oct 31, 2017
The blood-brain barrier is a collection of specialized cells and proteins that control the movement of molecules from the blood to the central nervous system.
DNA-Delivered Antibodies Fight Off Lethal Bacterial Infection
Catherine Offord | Oct 3, 2017
Mice receiving the treatment produced their own monoclonal antibodies and survived infection with the life-threatening pathogen Pseudomonas aeruginosa.
Tiny Motors Deliver Ulcer Medication in Mouse Stomachs
Shawna Williams | Aug 16, 2017
The mini machines treated infection somewhat better than antibiotics plus the typical proton pump inhibitor medication. 
Image of the Day: Teeny Tiny Delivery Balls
The Scientist Staff | Aug 3, 2017
Scientists designed autonomous nanovesicles capable of following glucose concentration gradients, even through the blood brain barrier in rats.