Opinion: New Models for ASDs

The study of mini “brains” in a dish, derived from patient cells, offers a novel approach for autism spectrum disorder research.

Written byAlysson R. Muotri
| 3 min read

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WIKIMEDIA, FOTOEDUKACJAThe complexity of the human brain, with thousands of different cell types and specialized communication networks, permits the development of sophisticated behavioral repertoires, such as language, self-awareness, cultural learning, and social interactions. However, the sophistication of the human brain can come at a cost—neurodevelopmental disorders, such as autism spectrum disorders (ASDs), can dramatically impair one’s ability to function in society.

People suffering from ASD can be vulnerable and dependent. Most intriguing is their capacity to experience their surroundings. People with autism may get upset when soap bubbles blast, for example, or when certain clothes touch their skin. A Christmas tree may appear to a person with ASD more impressive than a collision of stars. People with ASD have an intrinsic curiosity and learning is a constant addition to a forgetful memory. A few are savants, with extraordinary gifts that challenge researchers’ logical comprehension.

ASD individuals are mainly characterized by difficulties in social communication and the presence of focused repetitive or stereotyped behaviors, appearing within the first three years of life. The diagnosis and management of ASD relies in a combination of existing scientific knowledge, the ...

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