Opinion: New Models for ASDs

The study of mini “brains” in a dish, derived from patient cells, offers a novel approach for autism spectrum disorder research.

| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

WIKIMEDIA, FOTOEDUKACJAThe complexity of the human brain, with thousands of different cell types and specialized communication networks, permits the development of sophisticated behavioral repertoires, such as language, self-awareness, cultural learning, and social interactions. However, the sophistication of the human brain can come at a cost—neurodevelopmental disorders, such as autism spectrum disorders (ASDs), can dramatically impair one’s ability to function in society.

People suffering from ASD can be vulnerable and dependent. Most intriguing is their capacity to experience their surroundings. People with autism may get upset when soap bubbles blast, for example, or when certain clothes touch their skin. A Christmas tree may appear to a person with ASD more impressive than a collision of stars. People with ASD have an intrinsic curiosity and learning is a constant addition to a forgetful memory. A few are savants, with extraordinary gifts that challenge researchers’ logical comprehension.

ASD individuals are mainly characterized by difficulties in social communication and the presence of focused repetitive or stereotyped behaviors, appearing within the first three years of life. The diagnosis and management of ASD relies in a combination of existing scientific knowledge, the ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • Alysson R. Muotri

    This person does not yet have a bio.
Share
A greyscale image of cells dividing.
March 2025, Issue 1

How Do Embryos Know How Fast to Develop

In mammals, intracellular clocks begin to tick within days of fertilization.

View this Issue
Discover the history, mechanics, and potential of PCR.

Become a PCR Pro

Integra Logo
Explore polypharmacology’s beneficial role in target-based drug discovery

Embracing Polypharmacology for Multipurpose Drug Targeting

Fortis Life Sciences
3D rendered cross section of influenza viruses, showing surface proteins on the outside and single stranded RNA inside the virus

Genetic Insights Break Infectious Pathogen Barriers

Thermo Fisher Logo
A photo of sample storage boxes in an ultra-low temperature freezer.

Navigating Cold Storage Solutions

PHCbi logo 

Products

The Scientist Placeholder Image

Gilead’s Capsid Revolution Meets Our Capsid Solutions: Sino Biological – Engineering the Tools to Outsmart HIV

Stirling Ultracold

Meet the Upright ULT Built for Faster Recovery - Stirling VAULT100™

Stirling Ultracold logo
Chemidoc

ChemiDoc Go Imaging System ​

Bio-Rad
The Scientist Placeholder Image

Evotec Announces Key Progress in Neuroscience Collaboration with Bristol Myers Squibb