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B cells secreting antibodies that target virus particles.
Stem Cell Editing Repairs Severe Immunodeficiency
Scientists hoping to treat immunodeficiencies using gene therapy have found a way to edit stem cells in mice without disrupting gene regulation.
Stem Cell Editing Repairs Severe Immunodeficiency
Stem Cell Editing Repairs Severe Immunodeficiency

Scientists hoping to treat immunodeficiencies using gene therapy have found a way to edit stem cells in mice without disrupting gene regulation.

Scientists hoping to treat immunodeficiencies using gene therapy have found a way to edit stem cells in mice without disrupting gene regulation.

stem cells

High magnification image highlighting small hairlike projections called cilia, which help the biobots move.
A Leap Towards Building Synthetic Organisms 
Laura Tran, PhD | Mar 12, 2024 | 6 min read
Douglas Blackiston’s frog-fueled research seeks to push the boundaries of understanding developing organisms.
A graphic of two stem cells colored pink and blue splitting from each other, with binary code shown in the background.
Fixing the Problem With Induced Pluripotent Stem Cells
Tanvir Khan, PhD | Oct 31, 2023 | 4 min read
A new strategy prevents reprogramming-induced epigenetic aberrations in human induced pluripotent stem cells.
Exploring Stem Cell Strategies for Spinal Cord Repair
Exploring Stem Cell Strategies for Spinal Cord Repair
The Scientist Staff | 1 min read
In this webinar, Stephanie Willerth and Nisha Iyer will discuss the latest models that scientists use for testing the potential of endogenous and exogenous stem cell therapies for cell replacement and functional restoration following spinal cord injury.
A clinician holding a graphic of the lungs on a tablet
Stem Cells Breathe New Life into Lungs
Aparna Nathan, PhD | Oct 30, 2023 | 3 min read
New studies proposed using stem cells to make long-lasting lung grafts.
Fresh asparagus sliced horizontally, revealing inner microchannel structure.
Food for Thought: A Recipe for Regenerating Nerves
Iris Kulbatski, PhD | Oct 23, 2023 | 3 min read
Al dente asparagus stalks may hold the key to successful neural stem cell therapy for repairing injured axons.
Modeling Human Disease and Development with Organoids
Modeling Human Disease and Development with Organoids
The Scientist | 1 min read
Discover how scientists use cardiac and skin organoids to study differentiation and toxicity. 
A graphic of the female reproductive system
Differentiated Stem Cells Can Kickstart Fertility in Mice
Aparna Nathan, PhD | Oct 23, 2023 | 3 min read
Ovarian cells derived from stem cells restore hormones and cells needed to produce pups.
Melanocyte stem cells are shown in red and other cell nuclei are shown in blue.
Hair Turns Gray Due to Stuck Stem Cells
Mariella Bodemeier Loayza Careaga, PhD | Sep 8, 2023 | 3 min read
Hair-coloring stem cells must swing back and forth between their maturity states to give hair its color.
Best Practices for Organoid Technologies
Best Practices for Organoid Technologies 
The Scientist | 1 min read
Dosh Whye will discuss best practices for organoid modeling and how researchers leverage the latest technologies to achieve their goals.
This is an image of a bioluminescent from gene expression reporter in stem cells from a rhinoceros.
A Stem Cell Zoo Reveals Surprising Differences in Embryogenesis
Ida Emilie Steinmark, PhD | Sep 1, 2023 | 2 min read
By comparing stem cells from six mammals of different sizes, scientists discovered stark differences in embryonic development paces.
On the left is a normally developing mouse embryo, on the right is a slightly larger mouse embryo that also contains horse cells that glow green.
Chimera research opens new doors to understanding and treating disease
Hannah Thomasy, PhD, Drug Discovery News | Aug 9, 2023 | 10 min read
Animals with human cells could provide donor organs or help us understand neuropsychiatric disorders.
Key Strategies for Better Stem Cell Workflows
Solutions for Optimizing Stem Cell Therapy Development
Sartorius | 1 min read
Discover how process knowledge is integral to stem cell workflow improvement and optimization.
Conceptual image of hair loss showing trees in the shape of a human head at various seasonal stages of shedding their leaves.
Islands of Knowledge: Hairy Skin Moles Make Their Mark
Iris Kulbatski, PhD | Aug 7, 2023 | 3 min read
Skin moles that sprout thick, long hairs produce signaling molecules that stimulate hair follicle stem cells to initiate new hair growth. This discovery may make baldness a thing of the past.
Medical illustration of brain cancer with a microscopic magnification of malignant cells dividing in the tumor microenvironment.
Capturing the Brain Tumor Microenvironment with Tissue Engineering
Deanna MacNeil, PhD | Aug 4, 2023 | 3 min read
Researchers built a 3D glioblastoma model to study therapeutic resistance and improve drug screening systems.
Discover how counterflow centrifugation streamlines cell therapy workflows
Closed Cell Processing Systems for Cell Therapy Workflows
Thermo Fisher Scientific | 1 min read
Closed systems increase cell therapy manufacturing process efficiency.
Photo of Rosa Bacchetta, associate professor of pediatrics at Stanford University
The Future of Gene Therapy for a Rare Pediatric Autoimmune Disease
Niki Spahich, PhD | Jul 10, 2023 | 3 min read
By editing a mutated immune regulatory gene in patient cells, Rosa Bacchetta brings hope to those suffering from IPEX syndrome.
Neurons (green) fire differently depending on whether the astrocytes (red) they are grown with are cultivated from people with or without fragile X.
Astrocytes Fuel Erratic Firing in Fragile X Neurons
Lauren Schenkman, Spectrum | May 30, 2023 | 4 min read
This new understanding could one day lead to targeted treatments. 
 Learn how excessive oxygen availability during cell culture causes abnormal cell behavior 
What Oxygen Level Is Biologically Relevant For Cell Culture?
Thermo Fisher Scientific | 1 min read
Normoxic atmospheric conditions provide excessive oxygen availability, leading to abnormal cell behavior.
Bladder epithelial tissue, where cell junctions are shown in green and nuclei in blue. This was grown in vitro from cells taken from mice with chronic cystitis.
Bladder ‘Memory’ Influences Urinary Tract Infection Recurrence in Mice
Alejandra Manjarrez, PhD | Apr 12, 2023 | 3 min read
Urinary tract infections leave permanent epigenetic marks in the mouse bladder epithelium, reprogramming its response to subsequent infections, a study finds.
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