Opinion: On the Up and Up

An Amgen executive refutes accusations that the company published misleading results of its mid-90s clinical trial testing an anemia drug.

| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

WIKIMEDIA COMMONS, MDOUGM

Last month, medical professor Daniel Coyne of Washington University School of Medicine in St. Louis discussed the outcomes of a clinical trial that aimed to compare different treatment regimens for epoetin alfa, a drug often used to stimulate blood production in dialysis patients who suffer from anemia, which is characterized by a below-normal red blood cell count. The Normal Hematocrit Trial (NHT) was conducted in the mid-1990s by researchers at Amgen, the biotechnology company that manufactures epoetin alfa under the name-brand EPOGEN, and collaborating nephrologists.

After completing his own analysis of the trial data, which he obtained this March through a Freedom of Information Act request, Coyne claimed to have generated results that were “dramatically different” from those of our original report, published in the ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • Sean E. Harper

    This person does not yet have a bio.
Share
May digest 2025 cover
May 2025, Issue 1

Study Confirms Safety of Genetically Modified T Cells

A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.

View this Issue
iStock

TaqMan Probe & Assays: Unveil What's Possible Together

Thermo Fisher Logo
Meet Aunty and Tackle Protein Stability Questions in Research and Development

Meet Aunty and Tackle Protein Stability Questions in Research and Development

Unchained Labs
Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
How technology makes PCR instruments easier to use.

Making Real-Time PCR More Straightforward

Thermo Fisher Logo

Products

The Scientist Placeholder Image

Biotium Launches New Phalloidin Conjugates with Extended F-actin Staining Stability for Greater Imaging Flexibility

Leica Microsystems Logo

Latest AI software simplifies image analysis and speeds up insights for scientists

BioSkryb Genomics Logo

BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours

iStock

Agilent BioTek Cytation C10 Confocal Imaging Reader

agilent technologies logo