Biotium is a leading life science reagent manufacturer and supplier devoted to providing high-quality and innovative fluorescent tools that fuel scientific discovery. Our collaborative team of experienced chemists and biologists, who are at the forefront of fluorescent dye design, apply chemistry-based principles toward producing solutions for unmet challenges in life science and medical research. Since its founding in 2001, Biotium has developed over 30 patented technologies that have been licensed out to leading life science technology companies worldwide.
Unlike traditional lipophilic membrane dyes like DiO and DiI, CellBrite™ Fix dyes are fluorogenic lipophilic dyes that covalently bind the surface of live cells. The staining is simple, rapid, and much more uniform than other membrane dyes. Most importantly, surface staining is retained after fixation and permeabilization for immunofluorescence or other co-staining.
A rapid and inexpensive fluorescence method for screening conditions that affect protein thermal stability, such as protein mutations, ligand binding, and buffer formulations (like pH, salts, detergents, and other additives).
Mix-n-Stain™ Total Protein Prestain Kits are a new method for super-sensitive protein quantitation by SDS-PAGE or western blot. Using the kits, you can quickly and easily label proteins in lysates or purified proteins with near-infrared CF® dyes before electrophoresis and blotting. The labeling can detect as little as 1 ng protein in an SDS-PAGE gel.
Discover how single-molecule Fiber-seq is revealing unexpected mechanisms of transcription factor regulation, chromatin accessibility, and essential gene activation at CpG-island promoters.
Explore how emerging biomarker research and ultrasensitive multiplex proteomics are revealing molecular signatures associated with neurodegeneration, inflammation, and disease progression in amyotrophic lateral sclerosis (ALS).
Explore how in vivo CAR-neutrophil engineering and advanced light-sheet imaging are opening new avenues for studying and targeting glioblastoma and other solid tumors.
Explore practical strategies for designing, optimizing, and validating qPCR assays to improve specificity, reproducibility, and confidence across routine and high-throughput gene expression studies.
Automation can help to increase efficiency and reproducibility, but often comes at a significant cost. The ASSIST PLUS pipetting robot streamlines workflows at an affordable price, offering accessible automation with minimal programming requirements.
Corning® Cell Strainers are sterile, easy-to-use devices for rapidly isolating primary cells to consistently obtain a uniform single-cell suspension from tissues. Applications include stem cells and primary cells.
Real time imaging shouldn't outlast your cell surface stain. CellBrite® Steady: cell surface staining kits with fluorescent membrane dye plus enhancer for imaging live cell surface for several hours to days.
