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The RNA Conductome What can we learn from the in-process encyclopedia of how non-protein-coding sequences exert genetic control? The Scientist Staff Over the years, scientists and drug companies seeking genetic control over biological systems have focused their attention on proteins. But that's only one part of the picture: Recently, scientists have been accumulating evidence that non-protein-coding sequences often play the role of conductor in the body's response: it'

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5 HIV Treatment Strategies What the common cold virus, stem cells, and phylogeny can do to save the millions of people living with HIV. The Scientist Staff In 2006, 25 years after AIDS made its first appearance in the CDC's Morbidity and Mortality Weekly Report, an estimated 2.9 million people died of the illness. That same year, more than 4 million people were infected with HIV, joining the 35.2 million living with HIV/AIDS. Despite the dozens of approved treatments for th

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The Diseases Autoimmunity is transformed from an esoteric scientific challenge by the daily reality of millions of patients. So we begin with a description of the impact of autoimmune disease on patients, their families, society and healthcare systems. The depth of the challenges that underlie autoimmune diseases come through in painfully clear ways in the series of patient profiles starting on the next page. As described by Stephen

The Causes What causes autoimmune disease? Jeff Bluestone of the University of California, San Francisco - one of the world's leading authorities on the mechanisms behind autoimmunity - talks us through the pathways that trigger and fuel the internal battle to control the immune system. Thomas Dörner of the Charite University Hospital Berlin (see article here) and Yoshiyuki Ohsugi of Chugai Pharma