Proliferation organizes specification

Hox genes are a group of approximately 40 genes that control the anterior-posterior axial development in all animals that show such polarity. Much interest surrounds the precise regulation of this complex patterning, which depends inter alia upon qualitative and quantitative differences in Hox gene product levels in different tissues at different times. The expression pattern of this group of genes is described as temporal colinearity—genes are expressed in time in the same order that they appear on the genome—but the mechanism by which this transcription ordering is achieved has been unclear. In the July 15 EMBO Journal, Daniel Fisher and Marcel Mechali at the Centre National de la Recherche Scientifique, confirm that cellular proliferation has a primary role in the co-ordinated expression of the HoxB group of genes in two distinct systems, and demonstrate that the situation applies not only to Drosophila but to all vertebrates (The EMBO Journal, 22:3737-3748 ...