Stem Cell Trials in Peril?

The only US firm with an ongoing embryonic stem cell therapy clinical trial is in financial and legal hot water.

Written byKerry Grens
| 2 min read

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WIKIMEDIA, LD711The Massachusetts-based firm Advanced Cell Technology has been leading the way in the somewhat fraught pursuit of developing therapies using human embryonic stem cells. After the 2010 failure of the stem cell company Geron, subsequent progress in clinical studies from Advanced Cell Technology offered a glimmer of hope. But a news report from Nature this week tossed cold water on any excitement—apparently, the company is in trouble with the U.S. Securities and Exchange Commission (SEC) and is running out of money.

“This is a very painful time for them,” Gregory Bonfiglio, a venture capitalist with Proteus Venture Partners in Portola Valley, California, told Nature.

Advanced Cell Technology is currently running three Phase I clinical trials for degenerative eye diseases. Although the company intends to start the next round of clinical trials later this year, Nature pointed out that the firm’s most recent quarterly report revealed that the its funds could dissipate this year.

Late in 2013, the company paid out $4 million to settle an SEC charge of selling stocks without registering them. Last week, Advanced Cell Technology’s CEO, Gary Rabin, stepped down. Rabin is the subject of an ongoing SEC investigation. And to make matters worse, the Wisconsin Alumni Research Foundation is suing Advanced Cell ...

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  • kerry grens

    Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at WHYY in Philadelphia, and the health and science reporter at New Hampshire Public Radio. Kerry got her start in journalism as a AAAS Mass Media fellow at KUNC in Colorado. She has a master’s in biological sciences from Stanford University and a biology degree from Loyola University Chicago.

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