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A green and white fish swimming underwater
Rockfish Genes Hold Clues to Human Longevity
By analyzing the genomes of 23 remarkably long-lived fish species, a study found two metabolic pathways associated with longevity.
Rockfish Genes Hold Clues to Human Longevity
Rockfish Genes Hold Clues to Human Longevity

By analyzing the genomes of 23 remarkably long-lived fish species, a study found two metabolic pathways associated with longevity.

By analyzing the genomes of 23 remarkably long-lived fish species, a study found two metabolic pathways associated with longevity.

aging-related disease
A younger-looking mouse next to an older-looking one
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice
Alejandra Manjarrez, PhD | Jan 12, 2023 | 4 min read
Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.
a false color transmission electron microscope image of a neuronal cell body, with lysosomes colored dark green
Scientists Uncover Major Pathway Cells Use to Mend Leaky Lysosomes
Holly Barker | Oct 6, 2022 | 3 min read
Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.
White mice in a clear plastic cage
Different Genes Influence Lifespan in Male and Female Mice
Natalia Mesa, PhD | Sep 29, 2022 | 3 min read
Researchers say there may be similar, human genes whose effects on lifespan vary by sex.
3D rendered images of three T cell
T Cells Ward Off Aging with Help from Their Friends
Natalia Mesa, PhD | Sep 16, 2022 | 5 min read
Immune cells deliver packages of telomeres to T cells, helping them retain their virus-fighting function over time, research suggests.
Photo of Junyue Cao
Junyue Cao Applies Novel Approaches to Aging and Disease
Lisa Winter | Mar 14, 2022 | 3 min read
The Rockefeller University geneticist is tracing the full lifespan of individual cells to better understand how and why humans age.
An electron microscopy image of a cell with the nucleolus shown in blue, chromatin in green, and nuclear envelope in red
Aging in Mice Linked to Misexpression of Class of Genes
Sophie Fessl, PhD | Dec 21, 2021 | 4 min read
Genes lacking a particular structure known as CpG islands tend to go haywire in older cells, a study finds, potentially contributing to key facets of aging. But it’s not yet clear if the relationship is causal.
Fruit flies in a vial
Accurate Protein Production Promotes Longevity
Ruth Williams | Sep 15, 2021 | 3 min read
Worms, flies, and yeast live longer if the fidelity of their protein-making machinery is improved, a study shows.
Dietary Spermidine Boosts Cognition in Insects and Rodents
Ruth Williams | Apr 15, 2021 | 3 min read
Mice and flies given the polyamine in their diet have increased brain cell metabolism and cognitive function, and epidemiological data hints at a similar benefit in humans.
Pharma Looks to Inflammasome Inhibitors as All-Around Therapies
Rachael Moeller Gorman | Apr 1, 2021 | 10+ min read
Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.
Genetic Reprogramming Restores Vision in Mice: Study
Max Kozlov | Dec 6, 2020 | 5 min read
Researchers repaired what is otherwise irreversible damage in the animals’ ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells.
a patient getting blood drawn for testing
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
Shawna Williams | Nov 2, 2020 | 4 min read
The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.
Can Destroying Senescent Cells Treat Age-Related Disease?
Katarina Zimmer | Mar 1, 2020 | 10+ min read
A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.
Infographic: How Does Cell Senescence Drive Aging and Disease?
Katarina Zimmer | Mar 1, 2020 | 4 min read
The accumulation of zombie-like cells seems to accelerate aging and promote aging-related disease. Researchers are trying to figure out how.
Young Blood Unproven as Anti-Aging Treatment: US FDA
Carolyn Wilke | Feb 20, 2019 | 2 min read
The agency warns that plasma treatments costing thousands of dollars, which supposedly treat the infirmities of old age, have not been proven “safe or effective.”
Infographic: How Muscles Age
Gillian Butler-Browne, Vincent Mouly, Anne Bigot, and Capucine Trollet | Sep 1, 2018 | 1 min read
Numerous cellular changes underlie the decline of muscle mass and strength in the elderly.
Contributors
Sukanya Charuchandra | Sep 1, 2018 | 3 min read
Meet some of the people featured in the September 2018 issue of The Scientist.
How Muscles Age, and How Exercise Can Slow It
Gillian Butler-Browne, Vincent Mouly, Anne Bigot, and Capucine Trollet | Sep 1, 2018 | 10+ min read
Researchers untangle the multifarious nature of muscle aging. So far, the only reliable treatment is exercise.
Aging-Related Diseases May Be a Negative Outcome of Human Evolution
Sukanya Charuchandra | May 31, 2018 | 3 min read
Genetic adaptations for human brain development also make us vulnerable to Alzheimer’s disease, according to a new study.  
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