Photo of Junyue Cao
Junyue Cao Applies Novel Approaches to Aging and Disease
The Rockefeller University geneticist is tracing the full lifespan of individual cells to better understand how and why humans age.
ABOVE: Matthew Septimus, The Rockefeller University
Junyue Cao Applies Novel Approaches to Aging and Disease
Junyue Cao Applies Novel Approaches to Aging and Disease

The Rockefeller University geneticist is tracing the full lifespan of individual cells to better understand how and why humans age.

The Rockefeller University geneticist is tracing the full lifespan of individual cells to better understand how and why humans age.

ABOVE: Matthew Septimus, The Rockefeller University

aging-related disease

An electron microscopy image of a cell with the nucleolus shown in blue, chromatin in green, and nuclear envelope in red
Aging in Mice Linked to Misexpression of Class of Genes
Sophie Fessl | Dec 21, 2021
Genes lacking a particular structure known as CpG islands tend to go haywire in older cells, a study finds, potentially contributing to key facets of aging. But it’s not yet clear if the relationship is causal.
Fruit flies in a vial
Accurate Protein Production Promotes Longevity
Ruth Williams | Sep 15, 2021
Worms, flies, and yeast live longer if the fidelity of their protein-making machinery is improved, a study shows.
Dietary Spermidine Boosts Cognition in Insects and Rodents
Ruth Williams | Apr 15, 2021
Mice and flies given the polyamine in their diet have increased brain cell metabolism and cognitive function, and epidemiological data hints at a similar benefit in humans.
Pharma Looks to Inflammasome Inhibitors as All-Around Therapies
Rachael Moeller Gorman | Apr 1, 2021
Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.
Genetic Reprogramming Restores Vision in Mice: Study
Max Kozlov | Dec 6, 2020
Researchers repaired what is otherwise irreversible damage in the animals’ ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells.
a patient getting blood drawn for testing
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
Shawna Williams | Nov 2, 2020
The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.
Can Destroying Senescent Cells Treat Age-Related Disease?
Katarina Zimmer | Mar 1, 2020
A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.
Infographic: How Does Cell Senescence Drive Aging and Disease?
Katarina Zimmer | Mar 1, 2020
The accumulation of zombie-like cells seems to accelerate aging and promote aging-related disease. Researchers are trying to figure out how.
Young Blood Unproven as Anti-Aging Treatment: US FDA
Carolyn Wilke | Feb 20, 2019
The agency warns that plasma treatments costing thousands of dollars, which supposedly treat the infirmities of old age, have not been proven “safe or effective.”
Infographic: How Muscles Age
Gillian Butler-Browne, Vincent Mouly, Anne Bigot, Capucine Trollet | Sep 1, 2018
Numerous cellular changes underlie the decline of muscle mass and strength in the elderly.
Contributors
Sukanya Charuchandra | Sep 1, 2018
Meet some of the people featured in the September 2018 issue of The Scientist.
How Muscles Age, and How Exercise Can Slow It
Gillian Butler-Browne, Vincent Mouly, Anne Bigot, Capucine Trollet | Sep 1, 2018
Researchers untangle the multifarious nature of muscle aging. So far, the only reliable treatment is exercise.
Aging-Related Diseases May Be a Negative Outcome of Human Evolution
Sukanya Charuchandra | May 31, 2018
Genetic adaptations for human brain development also make us vulnerable to Alzheimer’s disease, according to a new study.