aneuploidy

When micronuclei rupture, chromosomes break, recombine, and form circles, causing inflammation and promoting carcinogenic growth.

The relatively new technique for visually detecting chromosomal variants associated with disease risk performs at least as well as more established techniques in two recent studies.

A “larger than life personality,” Amon devoted her career to studying the cell cycle and aneuploidy. Her research has shaped the field of cancer biology.

Eggs from girls and from older women show higher rates of errors in chromosome number.

A genomic analysis from 23andMe suggests that people inherit two copies of a chromosome from only one parent nearly twice as often as researchers had realized.

This year’s winners also include the developers of nusinersen, an oligonucleotide therapeutic for spinal muscular atrophy.

In the presence of cytosolic DNA, cancer cells activate antiviral pathways that disguise them as immune cells.

Errors in segregation during cell division can lead to inflammation in daughter cells.

Multiple DNA breaks at either the centromere or the long arm of the mouse Y chromosome cause it to fragment and disappear.

Science is messy. So lay it out, warts and all.

This year marks the centennial of Calvin Bridges’s description of nondisjunction as proof that chromosomes are vehicles for inheritance.

A recent exchange of papers is divided over the evidence for compensatory gene expression among wild strains of aneuploid yeast.

Meet some of the people featured in the May 2016 issue of The Scientist.

Why do so many human eggs have the wrong number of chromosomes?

Understanding why so many human oocytes contain the wrong number of chromosomes

The aneuploidy expert shares what she has learned at the American Association for Cancer Research annual meeting.

Scientists find a common genetic variant in mothers that decreases the chance of successful pregnancy.

Another company has launched a non-invasive DNA screen for genetic disorders in unborn babies, adding to the competition in an emerging market.