An illustration of a yeast cell (right) and a human neuron (left) showing the processes/features that are similar in the two
Infographic: Modeling Neurodegenerative Diseases with Yeast
Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.
ABOVE: © LISA CLARK
Infographic: Modeling Neurodegenerative Diseases with Yeast
Infographic: Modeling Neurodegenerative Diseases with Yeast

Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.

Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.

ABOVE: © LISA CLARK
autophagosome
Scanning electron micrograph (SEM) of the unicellular yeast Saccharomyces cerevisiae, known as Baker's or Brewer's yeast.
Yeast Models Provide New Insights into Neurodegenerative Diseases
Mahlon Collins | Oct 1, 2021
The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.
cartoon image of a brain against a black background
Humans Can Survive Without Key Autophagy Gene
Annie Melchor | Jul 19, 2021
Loss of the protein ATG7 is fatal in mice, but not always for people—although it is linked to human neurodevelopmental disorders, researchers report.
The Scientist’s Most Stunning Infographics of 2018
Jef Akst | Dec 21, 2018
From cellular self-digestion to the effects of exercise on the brain, our features editor picks her favorite art custom-made for the magazine.
Eat Yourself to Live: Autophagy’s Role in Health and Disease
Vikramjit Lahiri and Daniel J. Klionsky | Mar 1, 2018
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
Targeted ER Breakdown
Ashley P. Taylor | Jun 16, 2015
Researchers identify receptors that target the endoplasmic reticulum for degradation by autophagy in yeast and mice. 
On the Menu
Mary Beth Aberlin | Feb 1, 2012
Digestion on the cellular level: two mysteries examined
How Autophagy Works
Muriel Mari, Sharon A. Tooze, and Fulvio Reggiori | Feb 1, 2012
There are five steps of autophagosome biogenesis: induction, expansion, vesicle completion, fusion, and cargo degradation. 
The Enigmatic Membrane
Muriel Mari, Sharon A. Tooze, and Fulvio Reggiori | Feb 1, 2012
Despite years of research, the longstanding mystery of where the autophagosome gets its double lipid bilayers is not much clearer.