Move Over Apoptosis: Another Form of Cell Death May Occur in the Gut

Though scientists don’t yet know much about it, a newly described process called erebosis might have profound implications for how the gut maintains itself.

Written byNatalia Mesa, PhD
| 6 min read
Illustration of pseudostratified epithelial cells in early intestine, cells in red and nucleus in purple.
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Every day, billions of our cells die and new, healthy ones take their place. In a healthy gut lining, as in most tissues, a type of cell death called apoptosis is thought to mediate this process almost entirely on its own. But researchers from RIKEN in Kobe, Japan, suspect they have discovered a new kind of cell death in the gut of a fruit fly. The new process, which they call erebosis or “deep darkness,” may be present in other tissues, the team reports April 25 in PLOS Biology and if found in humans, it could affect how we understand diseases of the gastrointestinal tract.

María Domínguez Castellano, a neuroscientist at the Institute of Neurosciences in Alicante, Spain who didn’t work on the study, tells The Scientist she found the paper “very intriguing,” and hopes to see more from the researchers about the new putative form of cell death. “They’ve ...

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    As she was completing her graduate thesis on the neuroscience of vision, Natalia found that she loved to talk to other people about how science impacts them. This passion led Natalia to take up writing and science communication, and she has contributed to outlets including Scientific American and the Broad Institute. Natalia completed her PhD in neuroscience at the University of Washington and graduated from Cornell University with a bachelor’s degree in biological sciences. She was previously an intern at The Scientist, and currently freelances from her home in Seattle. 

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