autophagy

After 20 years, scientists studying patients with cerebellar degeneration discovered a mutation that disrupts autophagy.

An immune-inhibiting protein that regulates autophagy halts breast cancers from venturing across tissue borders.

Two autophagy genes work together to stop Mycobacterium tuberculosis dead in its tracks.

Cells use a variety of programmed cell death mechanisms to maintain homeostasis through cellular self-destruction, including apoptosis, necroptosis, and pyroptosis.

The Duke University cell biologist uses live-cell microscopy to reveal how brain cells rid themselves of damaged mitochondria and what goes wrong in neurodegenerative disease.

An unexpected find shows that sweet-sensing receptors also help epithelial cells in Drosophila larvae stay alive amid proteotoxic stress.

A team of scientists has found that in mice, a cellular housekeeping pathway protects against a major cause of heart attacks and strokes.

Robin Ketteler and Hélène Plun-Favreau discuss the importance of autophagy and mitophagy regulation in neurodegenerative diseases.

Though scientists don’t yet know much about it, a newly described process called erebosis might have profound implications for how the gut maintains itself.

New technologies allow researchers to scale up assays for cellular functions.

Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.

The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.

Loss of the protein ATG7 is fatal in mice, but not always for people—although it is linked to human neurodevelopmental disorders, researchers report.

The University of Pittsburgh scientist, who was studying SARS-CoV-2, was shot to death in his home.

Autophagy may keep cell division in check to help protect against cancer-causing DNA damage.

From cellular self-digestion to the effects of exercise on the brain, our features editor picks her favorite art custom-made for the magazine.

Researchers identify antibacterial functions of cell death in Arabidopsis when the plant is infected with Pseudomonas.  

New details of the molecular process by which our cells consume themselves point to therapeutic potential.

By stifling autophagy in the motor neurons of a mouse model of amyotrophic lateral sclerosis (ALS), scientists stem later-stage disease progression.