ADVERTISEMENT
Photo of Chantell Evans
Chantell Evans Tracks Mitochondrial Cleanup in Neurons
The Duke University cell biologist uses live-cell microscopy to reveal how brain cells rid themselves of damaged mitochondria and what goes wrong in neurodegenerative disease.
Chantell Evans Tracks Mitochondrial Cleanup in Neurons
Chantell Evans Tracks Mitochondrial Cleanup in Neurons

The Duke University cell biologist uses live-cell microscopy to reveal how brain cells rid themselves of damaged mitochondria and what goes wrong in neurodegenerative disease.

The Duke University cell biologist uses live-cell microscopy to reveal how brain cells rid themselves of damaged mitochondria and what goes wrong in neurodegenerative disease.

autophagy
A colored microscopy image showing cells that are dying in yellow and healthy cells in blue 
Sweet Taste Receptors Regulate Proteins in Developing Fruit Flies
Tess Joosse | Nov 14, 2022 | 2 min read
An unexpected find shows that sweet-sensing receptors also help epithelial cells in Drosophila larvae stay alive amid proteotoxic stress.
A colored microscope image of a cross section of a human artery filled with fatty plaques
Protein-Recycling Process Protective Against Arterial Plaques
Clare Watson | Aug 1, 2022 | 2 min read
A team of scientists has found that in mice, a cellular housekeeping pathway protects against a major cause of heart attacks and strokes.
Autophagy and Mitophagy in Neurodegeneration: A Deep Dive
Autophagy and Mitophagy in Neurodegeneration: A Deep Dive
The Scientist Creative Services Team and PerkinElmer | 1 min read
Robin Ketteler and Hélène Plun-Favreau discuss the importance of autophagy and mitophagy regulation in neurodegenerative diseases.
A drawing of pseudostratified gut epithelial cells in the early intestines, cells in red and nucleus in purple.
Move Over Apoptosis: Another Form of Cell Death May Occur in the Gut
Natalia Mesa, PhD | May 18, 2022 | 6 min read
Though scientists don’t yet know much about it, a newly described process called erebosis might have profound implications for how the gut maintains itself.
An illustration of a yeast cell (right) and a human neuron (left) showing the processes/features that are similar in the two
Infographic: Modeling Neurodegenerative Diseases with Yeast
Mahlon Collins | Oct 1, 2021 | 3 min read
Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.
Discover how to scale up cellular assays during drug discovery
High-Throughput Solutions for Lead Candidate Discovery
The Scientist Creative Services Team and Thermo Fisher Scientific | 1 min read
New technologies allow researchers to scale up assays for cellular functions.
Scanning electron micrograph (SEM) of the unicellular yeast Saccharomyces cerevisiae, known as Baker's or Brewer's yeast.
Yeast Models Provide New Insights into Neurodegenerative Diseases
Mahlon Collins | Oct 1, 2021 | 10+ min read
The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.
cartoon image of a brain against a black background
Humans Can Survive Without Key Autophagy Gene
Annie Melchor | Jul 19, 2021 | 4 min read
Loss of the protein ATG7 is fatal in mice, but not always for people—although it is linked to human neurodevelopmental disorders, researchers report.
bing liu university of pittsburgh school of medicine
Computational Biologist Bing Liu Dies in Suspected Murder
Kerry Grens | May 7, 2020 | 1 min read
The University of Pittsburgh scientist, who was studying SARS-CoV-2, was shot to death in his home.
Image of the Day: Cellular Breakdown
Carolyn Wilke | Jan 31, 2019 | 1 min read
Autophagy may keep cell division in check to help protect against cancer-causing DNA damage.
The Scientist’s Most Stunning Infographics of 2018
Jef Akst | Dec 21, 2018 | 2 min read
From cellular self-digestion to the effects of exercise on the brain, our features editor picks her favorite art custom-made for the magazine.
Image of the Day: Pseudomonas Autophagy
The Scientist Staff and The Scientist Staff | Mar 30, 2018 | 1 min read
Researchers identify antibacterial functions of cell death in Arabidopsis when the plant is infected with Pseudomonas.  
Eat Yourself to Live: Autophagy’s Role in Health and Disease
Vikramjit Lahiri and Daniel J. Klionsky | Mar 1, 2018 | 10+ min read
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
Image of the Day: When Cells Stop Cleaning
The Scientist Staff | Sep 12, 2017 | 1 min read
By stifling autophagy in the motor neurons of a mouse model of amyotrophic lateral sclerosis (ALS), scientists stem later-stage disease progression.
Vlad Denic on Exploring New Fields and Failing Successfully
Ben Andrew Henry | Dec 1, 2016 | 3 min read
The Harvard professor is pursuing fundamental questions about autophagy, protein homeostasis, and other cellular processes, and he’s always on the lookout for his next new topic.
Autophagy Pioneer Wins Nobel
Kerry Grens | Oct 2, 2016 | 3 min read
Biologist Yoshinori Ohsumi is honored for his discoveries on the mechanisms of cellular recycling.
Cocaine Induces Neuronal Autophagy
Jef Akst | Jan 19, 2016 | 1 min read
A new study supports the idea that cocaine triggers brain cells to eat themselves and suggests a possible antidote.
Targeted ER Breakdown
Ashley P. Taylor | Jun 16, 2015 | 3 min read
Researchers identify receptors that target the endoplasmic reticulum for degradation by autophagy in yeast and mice. 
Toggling Between Life and Death
Ashley P. Taylor | Apr 1, 2015 | 2 min read
In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.
ADVERTISEMENT