A colored microscope image of a cross section of a human artery filled with fatty plaques
Protein-Recycling Process Protective Against Arterial Plaques
A team of scientists has found that in mice, a cellular housekeeping pathway protects against a major cause of heart attacks and strokes.
Protein-Recycling Process Protective Against Arterial Plaques
Protein-Recycling Process Protective Against Arterial Plaques

A team of scientists has found that in mice, a cellular housekeeping pathway protects against a major cause of heart attacks and strokes.

A team of scientists has found that in mice, a cellular housekeeping pathway protects against a major cause of heart attacks and strokes.

autophagy
A drawing of pseudostratified gut epithelial cells in the early intestines, cells in red and nucleus in purple.
Move Over Apoptosis: Another Form of Cell Death May Occur in the Gut
Natalia Mesa | May 18, 2022
Though scientists don’t yet know much about it, a newly described process called erebosis might have profound implications for how the gut maintains itself.
An illustration of a yeast cell (right) and a human neuron (left) showing the processes/features that are similar in the two
Infographic: Modeling Neurodegenerative Diseases with Yeast
Mahlon Collins | Oct 1, 2021
Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.
Autophagy and Mitophagy in Neurodegeneration: A Deep Dive
Autophagy and Mitophagy in Neurodegeneration: A Deep Dive
The Scientist Creative Services Team and PerkinElmer
Robin Ketteler and Hélène Plun-Favreau discuss the importance of autophagy and mitophagy regulation in neurodegenerative diseases.
Scanning electron micrograph (SEM) of the unicellular yeast Saccharomyces cerevisiae, known as Baker's or Brewer's yeast.
Yeast Models Provide New Insights into Neurodegenerative Diseases
Mahlon Collins | Oct 1, 2021
The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.
cartoon image of a brain against a black background
Humans Can Survive Without Key Autophagy Gene
Annie Melchor | Jul 19, 2021
Loss of the protein ATG7 is fatal in mice, but not always for people—although it is linked to human neurodevelopmental disorders, researchers report.
Discover how to scale up cellular assays during drug discovery
High-Throughput Solutions for Lead Candidate Discovery
The Scientist Creative Services Team and Thermo Fisher Scientific
New technologies allow researchers to scale up assays for cellular functions.
bing liu university of pittsburgh school of medicine
Computational Biologist Bing Liu Dies in Suspected Murder
Kerry Grens | May 7, 2020
The University of Pittsburgh scientist, who was studying SARS-CoV-2, was shot to death in his home.
Image of the Day: Cellular Breakdown
Carolyn Wilke | Jan 31, 2019
Autophagy may keep cell division in check to help protect against cancer-causing DNA damage.
The Scientist’s Most Stunning Infographics of 2018
Jef Akst | Dec 21, 2018
From cellular self-digestion to the effects of exercise on the brain, our features editor picks her favorite art custom-made for the magazine.
Image of the Day: Pseudomonas Autophagy
The Scientist Staff and The Scientist Staff | Mar 30, 2018
Researchers identify antibacterial functions of cell death in Arabidopsis when the plant is infected with Pseudomonas.  
Eat Yourself to Live: Autophagy’s Role in Health and Disease
Vikramjit Lahiri and Daniel J. Klionsky | Mar 1, 2018
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
Image of the Day: When Cells Stop Cleaning
The Scientist Staff | Sep 12, 2017
By stifling autophagy in the motor neurons of a mouse model of amyotrophic lateral sclerosis (ALS), scientists stem later-stage disease progression.
Vlad Denic on Exploring New Fields and Failing Successfully
Ben Andrew Henry | Dec 1, 2016
The Harvard professor is pursuing fundamental questions about autophagy, protein homeostasis, and other cellular processes, and he’s always on the lookout for his next new topic.
Autophagy Pioneer Wins Nobel
Kerry Grens | Oct 2, 2016
Biologist Yoshinori Ohsumi is honored for his discoveries on the mechanisms of cellular recycling.
Cocaine Induces Neuronal Autophagy
Jef Akst | Jan 19, 2016
A new study supports the idea that cocaine triggers brain cells to eat themselves and suggests a possible antidote.
Targeted ER Breakdown
Ashley P. Taylor | Jun 16, 2015
Researchers identify receptors that target the endoplasmic reticulum for degradation by autophagy in yeast and mice. 
Toggling Between Life and Death
Ashley P. Taylor | Apr 1, 2015
In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.
Synaptic Pruning Improves Autism in Mice
Kerry Grens | Aug 25, 2014
Fixing impaired pruning and autophagy signaling in neurons eases the symptoms of autism in a mouse model of the disorder.
Autophagy Revives Dying Cancer Cells
Kerry Grens | Apr 7, 2014
Self digestion thwarts self destruction.