Drugging the Undruggable

Learn how cutting-edge strategies empower researchers to target undruggable proteins.

Drugging the Undruggable

Learn how cutting-edge strategies empower researchers to target undruggable proteins.

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chemical probe

chemical probe

Researchers at the University of Arizona developed a pH-responsive probe that activated in the basic environment (purple) of the larval midgut and bound to gut proteins.

Gut-Powered Mosquito Probes

Laura Tran, PhD | Sep 16, 2024 | 2 min read

With the rise of insecticide resistance, researchers crafted a novel probe that selectively targets mosquito larvae’s weak spot.

New Resource Ranks Chemical Probes for Human Proteins

Abby Olena, PhD | Dec 14, 2017 | 3 min read

With many probes being seriously flawed, Probe Miner helps researchers find those that are most specific and effective for manipulating their chosen proteins.