DNA damage response
PARP Inhibitors Are Improving the Outlook of Hard-to-Treat Cancers
PARP Inhibitors Are Improving the Outlook of Hard-to-Treat Cancers
Vicki Brower | Apr 1, 2018
With three recent FDA approvals, and a number of Phase 3 trials ongoing, the drugs are seeing a surge in interest.
Alcohol Damages Mouse DNA
Alcohol Damages Mouse DNA
Jef Akst | Jan 3, 2018
A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.
Noncoding RNA Helps Cells Recover from DNA Damage
Noncoding RNA Helps Cells Recover from DNA Damage
Diana Kwon | May 1, 2017
Scientists discover transcripts from the same gene that can express both proteins and noncoding RNA.
 
Wrangling Retrotransposons
Wrangling Retrotransposons
Andrei Seluanov, Michael Van Meter, Vera Gorbunova | Mar 1, 2015
These mobile genetic elements can wreak havoc on the genome. Researchers are now trying to understand how such activity contributes to the aging process.
How We Age
How We Age
The Scientist Staff | Mar 1, 2015
From DNA damage to cellular miscommunication, aging is a mysterious and multifarious process.
DNA Damage Scout
DNA Damage Scout
Andrew P. Han | Feb 11, 2014
Researchers are beginning to appreciate a role for RNA polymerase beyond gene transcription.
Brain Activity Breaks DNA
Brain Activity Breaks DNA
Sabrina Richards | Mar 24, 2013
Researchers find that temporary double-stranded DNA breaks commonly result from normal neuron activation—but expression of an Alzheimer’s-linked protein increases the damage.
DNA, Contortionist
Kerry Grens | Aug 1, 2012
The DNA forms known as G-quadruplexes are finally discovered in human cells.
Daniel Durocher: Change is Good
Kerry Grens | Jul 1, 2012
Senior Investigator, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada. Age 40