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Bishoy Faltas investigates how chemotherapy, extrachromosomal DNA, and a gene-editing protein create the perfect storm for bladder cancer therapeutic resistance.

DNA damage response

How Plants Protect Their DNA in Space 

To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

Infographic: DNA Damage Viewed with Unprecedented Clarity

Broken DNA

DNA Damage Viewed with Unprecedented Clarity

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Bridging Disciplines to Study CRISPR-Induced Chromosome Destabilization

Bacteriophage (green) attacking a bacterium (orange)

Bacteria Set Off Viral “Bombs” Inside Neighbors

illustration of a broken DNA strand

DNA Damage Makes Zebrafish Sleepy

Stress-Induced Chromosome Changes Protect Flies’ Aging Brains

PARP Inhibitors Are Improving the Outlook of Hard-to-Treat Cancers

Alcohol Damages Mouse DNA

Noncoding RNA Helps Cells Recover from DNA Damage

Wrangling Retrotransposons

How We Age

DNA Damage Scout

Brain Activity Breaks DNA

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DNA, Contortionist

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Daniel Durocher: Change is Good

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Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

A woman eating chocolate.

Why Do Some Women Crave Chocolate Before Their Period?

An MRI image of a human brain, with a glowing red section which indicates a tumor.

Why Are Breast Cancers That Metastasize to the Brain Hard to Treat?

An anatomical drawing of the placenta showing vascularization and the umbilical cord.

How Can the Placenta Help Us Understand Cancer?

Multimedia

Graphic of silver and gold 3D spheres levitating in space

Transform Omics Workflows with Scalable Cell Prep

LevitasBio
Conceptual image of genomic analysis showing multicolored DNA base sequences depicted as the letters C, G, A, and T.

Accelerating Cancer Research Through Comprehensive Genomic Analysis

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May digest 2025 cover
May 2025, Issue 1

Study Confirms Safety of Genetically Modified T Cells

A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.

View this Issue
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TaqMan Probe & Assays: Unveil What's Possible Together

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Meet Aunty and Tackle Protein Stability Questions in Research and Development

Meet Aunty and Tackle Protein Stability Questions in Research and Development

Unchained Labs
Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
How technology makes PCR instruments easier to use.

Making Real-Time PCR More Straightforward

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Fujirebio Receives Marketing Clearance for Lumipulse® G pTau 217/ β-Amyloid 1-42 Plasma Ratio In-Vitro Diagnostic Test

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Biotium Launches New Phalloidin Conjugates with Extended F-actin Staining Stability for Greater Imaging Flexibility

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Latest AI software simplifies image analysis and speeds up insights for scientists

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BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours