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Bishoy Faltas investigates how chemotherapy, extrachromosomal DNA, and a gene-editing protein create the perfect storm for bladder cancer therapeutic resistance.

DNA damage response

How Plants Protect Their DNA in Space 

To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

Infographic: DNA Damage Viewed with Unprecedented Clarity

Broken DNA

DNA Damage Viewed with Unprecedented Clarity

Abstract Genetics Disease stock photo

Bridging Disciplines to Study CRISPR-Induced Chromosome Destabilization

Bacteriophage (green) attacking a bacterium (orange)

Bacteria Set Off Viral “Bombs” Inside Neighbors

illustration of a broken DNA strand

DNA Damage Makes Zebrafish Sleepy

Stress-Induced Chromosome Changes Protect Flies’ Aging Brains

PARP Inhibitors Are Improving the Outlook of Hard-to-Treat Cancers

Alcohol Damages Mouse DNA

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A cross section of a pine stem shows cells stained purple and blue.

The Biggest Breakthroughs in Cell Biology in 2025

Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

Gollum, the extremely territorial character from The Lord of the Rings, famous for his line, “My precious,” sits on a rock, looking up.

The Gollum Effect: 44 Percent of Scientists Report Territorial Research Experiences

person doing the finger prick test for measuring blood glucose. A new noninvasive method could provide an alternative to such invasive blood tests.

Measuring Blood Sugar Without Painful Pricks? A New Test Scans Skin

Multimedia

Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

Merck
Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

MilliporeSigma purple logo
December digest cover image of a wooden sculpture comprised of multiple wooden neurons that form a seahorse.
December 2025, Issue 1

Wooden Neurons: An Artistic Vision of the Brain

A neurobiologist, who loves the morphology of cells, turns these shapes into works of art made from wood.

View this Issue
Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

Merck
Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

MilliporeSigma purple logo
Human iPSC-derived Models for Brain Disease Research

Human iPSC-derived Models for Neurodegenerative Disease Research

Fujifilm
Abstract wireframe sphere with colorful dots and connecting lines representing the complex cellular and molecular interactions within the tumor microenvironment.

Exploring the Inflammatory Tumor Microenvironment 

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BRANDTECH® Scientific Announces Strategic Partnership with Copia Scientific to Strengthen Sales and Service of the BRAND® Liquid Handling Station (LHS) 

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Enter Our 2026 Top Innovations Contest

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Biotium Expands Tyramide Signal Amplification Portfolio with Brighter and More Stable Dyes for Enhanced Spatial Imaging

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LabVantage Solutions Awarded $22.3 Million U.S Customs and Border Protection Contract to Deliver Next-Generation Forensic LIMS