DNA damage response

Buildup of a DNA-repair protein in brain cells spurs shut-eye in the fish, a study finds, and similar results in mice suggest the mechanism is widespread in animals.

Brain cells in older Drosophila tend to have more than two complete sets of chromosomes, and that polyploidy most likely has a protective function, a study shows.

With three recent FDA approvals, and a number of Phase 3 trials ongoing, the drugs are seeing a surge in interest.

A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.

Scientists discover transcripts from the same gene that can express both proteins and noncoding RNA.
 

These mobile genetic elements can wreak havoc on the genome. Researchers are now trying to understand how such activity contributes to the aging process.

From DNA damage to cellular miscommunication, aging is a mysterious and multifarious process.

Researchers are beginning to appreciate a role for RNA polymerase beyond gene transcription.

Researchers find that temporary double-stranded DNA breaks commonly result from normal neuron activation—but expression of an Alzheimer’s-linked protein increases the damage.

The DNA forms known as G-quadruplexes are finally discovered in human cells.

Senior Investigator, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada. Age 40