A close-up of a computer-generated tardigrade.
| 3 min read
Boosting cells with a tardigrade protein reduced DNA damage after radiation, offering potential protection for healthy tissue during cancer treatment.

DNA double-stranded breaks

A younger-looking mouse next to an older-looking one

Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice

To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

Infographic: DNA Damage Viewed with Unprecedented Clarity

Broken DNA

DNA Damage Viewed with Unprecedented Clarity

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Without This Enzyme, Insertions Thrive in the Yeast Genome

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Infographic: How Stray DNA Can Land in Double-Strand Breaks

Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine

Brain Activity Breaks DNA

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Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

Green clusters of moss on a petri dish against a white background.

Moss Medicines: The Next Revolution in Biotech?

An obese mouse on the left compared with normal control on right.

How Cysteine Depletion Drives Cells to Burn Fat 

A watercolor illustration of the human brain.

New Neurons Continue to Form in Adult Human Brains

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Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

A large number of stylized antibodies

The Holy Grail Hunt in De Novo Antibody Design

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July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

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Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

Explore synthetic DNA’s many applications in cancer research

Weaving the Fabric of Cancer Research with Synthetic DNA

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Illustrated plasmids in bright fluorescent colors

Enhancing Elution of Plasmid DNA

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An illustration of green lentiviral particles.

Maximizing Lentivirus Recovery

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Products

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Introducing the iQue 5 HTS Platform: Empowering Scientists  with Unbeatable Speed and Flexibility for High Throughput Screening by Cytometry

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Vanderbilt Selects Parse Biosciences GigaLab to Generate Atlas of Early Neutralizing Antibodies to Measles, Mumps, and Rubella

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Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery