A close-up of a computer-generated tardigrade.
| 3 min read
Boosting cells with a tardigrade protein reduced DNA damage after radiation, offering potential protection for healthy tissue during cancer treatment.

DNA double-stranded breaks

A younger-looking mouse next to an older-looking one

Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice

To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

Infographic: DNA Damage Viewed with Unprecedented Clarity

Broken DNA

DNA Damage Viewed with Unprecedented Clarity

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Without This Enzyme, Insertions Thrive in the Yeast Genome

the literature infographic dna repairing

Infographic: How Stray DNA Can Land in Double-Strand Breaks

Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine

Brain Activity Breaks DNA

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Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

A close-up image of a fly landing on a dessert

What Happens When a Fly Lands on Your Food? 

Red and green small tomatoes. A new genetic engineering approach helped gene-edited plants grow faster.

Gene-Edited Crops Grow Faster with a Little Help from Bacteria

Image of an infant’s feet that are visible in a hospital incubator.

Record-Breaking DNA Sequencing Technology Could Transform Newborn Care

Multimedia

Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

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Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

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Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

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Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

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LabVantage Solutions Awarded $22.3 Million U.S Customs and Border Protection Contract to Deliver Next-Generation Forensic LIMS

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Evosep Unveils Open Innovation Initiative to Expand Standardization in Proteomics

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OGT expands MRD detection capabilities with new SureSeq Myeloid MRD Plus NGS Panel