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Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice
Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.
Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.
double-strand breaks
Improving CRISPR Homology-Directed Repair (HDR) Rates
Integrated DNA Technologies (IDT) | Jan 31, 2022 | 1 min read
Improved reagents and careful donor design boost HDR rates for genome engineering.
DNA Damage Makes Zebrafish Sleepy
Sophie Fessl, PhD | Nov 18, 2021 | 4 min read
Buildup of a DNA-repair protein in brain cells spurs shut-eye in the fish, a study finds, and similar results in mice suggest the mechanism is widespread in animals.
Without This Enzyme, Insertions Thrive in the Yeast Genome
Katarina Zimmer | Mar 1, 2019 | 3 min read
A study underscores the importance of Dna2 in maintaining the integrity of the genetic code.
Infographic: How Stray DNA Can Land in Double-Strand Breaks
Katarina Zimmer | Mar 1, 2019 | 1 min read
A study on yeast illuminates how insertions may occur.
Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine
Catherine Offord | Oct 25, 2017 | 8 min read
With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.
Cranking Out New Models
Kate Yandell | May 6, 2013 | 2 min read
Scientists make mice strains with multiple mutations in less than a month without using embryonic stem cells.
Why Women’s Eggs Don’t Last
Kate Yandell | Feb 13, 2013 | 3 min read
As reproductive tissues age, DNA repair mechanisms become less efficient, causing genomic damage to accumulate.
Daniel Durocher: Change is Good
Kerry Grens | Jul 1, 2012 | 3 min read
Senior Investigator, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada. Age 40