double-strand breaks

Improved reagents and careful donor design boost HDR rates for genome engineering.

Buildup of a DNA-repair protein in brain cells spurs shut-eye in the fish, a study finds, and similar results in mice suggest the mechanism is widespread in animals.

A study underscores the importance of Dna2 in maintaining the integrity of the genetic code.

A study on yeast illuminates how insertions may occur.

With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.

Scientists make mice strains with multiple mutations in less than a month without using embryonic stem cells.

As reproductive tissues age, DNA repair mechanisms become less efficient, causing genomic damage to accumulate.

Senior Investigator, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada. Age 40