drug resistance

Researchers studying lung cancer cell lines found that chromatin remodeling underlies one type of osimertinib resistance.

The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment.

Recent studies describe how resident microbiota appear to outcompete unwelcome visitors, either with superior weaponry or by guzzling up local resources.  

In a first, patients who hadn’t been treated with antifungals were found to carry Candida auris impervious to all three available classes of the drugs.

Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.

Strategies to trick, manipulate, and direct the evolution of tumors

New therapeutic approaches in oncology aim to manipulate or block cancer’s adaptation to treatment.

Colorectal tumor cells limit their DNA repair in response to a targeted therapy, giving them a greater chance to develop resistance to the drug.

The US Food and Drug Administration green lights a therapy for an extreme form of multidrug resistant TB.

The agency issued a safety warning after two patients contracted antibiotic-resistant infections and one of the patients died.

Fungal researcher Christina Cuomo discusses the spread of infections plaguing hospitals across the world.

The parasite that causes malaria has evolved to evade many of the drugs that researchers have developed to fight the tropical disease.

Plasmodium falciparum has shown an ability to evade everything we throw at it, most recently artemisinin-based combination therapies, today’s front-line treatment.