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Confocal image of a developing embryo with blue-labeled nuclei and orange stained edges.
Unraveling the Complex Mysteries of Embryonic Beginnings
Magdalena Zernicka-Goetz followed the aesthetic allure of the embryo to better understand the start of development.
Unraveling the Complex Mysteries of Embryonic Beginnings
Unraveling the Complex Mysteries of Embryonic Beginnings

Magdalena Zernicka-Goetz followed the aesthetic allure of the embryo to better understand the start of development.

Magdalena Zernicka-Goetz followed the aesthetic allure of the embryo to better understand the start of development.

embryonic development

Image of an embryo built from Lego bricks showing cell populations in green and red.
Stem Cell-Based Embryo Models Add a Dimension to Developmental Biology
Shelby Bradford, PhD | Sep 13, 2024 | 10+ min read
Studying human embryonic development is complicated for several reasons. Models derived from pluripotent stem cells representing distinct stages offer a path to studying this process.
Embryoid bodies, at the top of the page, are a cluster of embryonic stem cells (ESCs) that differentiate portions into ectoderm (orange), mesoderm (dark blue), and endoderm (pink).
Infographic: The Many Paths to Stem Cell-Based Embryo Models
Shelby Bradford, PhD | Sep 13, 2024 | 5 min read
Culturing pluripotent stem cells to replicate different stages of embryonic development allows researchers to more easily investigate this period.
A mouse stands behind a toy table with two pieces of food on it.
A Protein-Sensing Molecular Switch Alters Facial Features
Shelby Bradford, PhD | Jun 24, 2024 | 3 min read
The mTORC1 signaling pathway senses nutritional information and influences craniofacial development in mice.
A developing embryo with DNA labeled blue, cell boundaries labeled pink, and certain cells fluorescing green.
The First Two Cells in a Human Embryo Contribute Disproportionately to Fetal Development
Shelby Bradford, PhD | May 13, 2024 | 4 min read
A research team showed that, contrary to current models, one early embryonic cell dominates lineages that will become the fetus.
Fluorescent microscopy image of an embryo model representing four tissue layers of this developmental stage. Cyan-labeled cells are clustered at the top of an ovoid structure, underneath them are yellow-labeled cells and under them red-labeled cells, and surrounding all three layers are white labeled cells.
The First Human Embryo Model From Embryonic Stem Cells
Shelby Bradford, PhD | Mar 1, 2024 | 2 min read
Jacob Hanna developed a method for replicating embryogenesis outside of the uterus to understand the underlying mechanisms.
Embryonic gecko hand
Science Snapshot: Show of Hands
Lisa Winter | Oct 28, 2022 | 1 min read
This image took the top prize at the 2022 Nikon Small World Photomicrography Competition.
Illustration of a human and Neanderthal skull side by side.
Mutation Linked to Difference Between Human and Neanderthal Brains
Dan Robitzski | Sep 9, 2022 | 5 min read
A single amino acid substitution in a protein causes increased neuron production in the frontal lobes of humans compared to Neanderthals—a tiny difference that could have given our species a cognitive edge, researchers say.
microscope image series showing synthetic embryo development
Mouse Embryo: No Sperm, Egg, or Uterus Required
Christie Wilcox, PhD | Aug 2, 2022 | 3 min read
Using stem cells and a bioreactor, researchers generated living embryos that survived for more than a week and began to develop internal organs.
Microscopy image of a cricket embryo, illuminated in green, pinched near one end, with one side full of bright green dots representing cell nuclei
How Wandering Nuclei Shape Developing Embryos
Viviane Callier | Jul 29, 2022 | 3 min read
As cricket blastoderms form, cell nuclei are pulled into an egg’s remaining empty space to form the new cell layers that will shape the developing animal.
Photo of older woman dressed in blue smiling and looking at the camera
Cancer Researcher Beatrice Mintz Dies at 100
Natalia Mesa, PhD | Jan 20, 2022 | 2 min read
Mintz’s experiments over her six-decade career were foundational to cancer and genetics research.
Conceptual image of an embryo with sound waves
Embryonic Eavesdropping: How Animals Hear and Respond to Sound
Amanda Heidt | Nov 1, 2021 | 10+ min read
Recent findings buck the traditional idea that embryos are passive agents and instead suggest that by tuning into vibrations, organisms can better prepare to enter the outside world.
silhouette of a chimpanzee swinging against a blue sky
Alu Leap May Explain Why Apes Don’t Have Tails
Annie Melchor | Sep 23, 2021 | 2 min read
A transposable element that jumped into the TBXT gene, which is linked to tail morphology, appears to be to blame for our missing appendage.
Human-Monkey Chimeras Shed Light on Development
Abby Olena, PhD | Apr 15, 2021 | 3 min read
Human stem cells injected into early monkey embryos proliferate and contribute to multiple cell lineages over 20 days of embryonic development.
Lab-Grown Mouse Embryos Form Limbs and Organs
Lisa Winter | Mar 19, 2021 | 3 min read
The embryos completed one-third of their total gestation outside of a uterus.
Identical Twins Accumulate Genetic Differences in the Womb
Catherine Offord | Jan 7, 2021 | 4 min read
DNA replication errors during cell division cause monozygotic twins to diverge from each other even during the earliest stages of development, a new study finds.
Early Embryo Models Generated from Mouse Stem Cells
Abby Olena, PhD | Oct 17, 2019 | 4 min read
Extended pluripotent stem cells from mice can self-organize to form blastocyst-like structures called blastoids that enable a closer look at early mammalian development.
Image of the Day: Cellular Tracks
Carolyn Wilke | Jan 21, 2019 | 1 min read
To study the fate of stem cells in developing chick embryos, researchers trace their steps over time.
First Mouse Embryos Made from Two Fathers
Abby Olena, PhD | Oct 11, 2018 | 3 min read
The bipaternal pups died soon after birth, but mice with two mothers grew into fertile adults.
Image of the Day: The Birth of a Nervous System
Jef Akst | Oct 2, 2018 | 1 min read
The winner of the 2018 Nikon Small World in Motion video competition shows the development of sensory neurons in a zebrafish embryo.
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