Despite recent advances in the study of eukaryogenesis, much remains unresolved about the origin and evolution of the most complex domain of life.

A lot happened in the hundreds of millions years separating the first and last eukaryotic common ancestors, but when and how most features arose remains a mystery.

Guthrie established foundational concepts in the field of pre-mRNA splicing during her career at the University of California, San Francisco.

Horizontally transferred genes play significant roles in eukaryotic genomes

The discovery that a group of cell-infecting bacteria lived roughly 2 billion years ago stirs a longstanding controversy around which came first: phagocytosis or mitochondria.

Phylogenomics data place the enigmatic plankton in the middle of the algal family tree, despite their apparent lack of plastids—an organelle characteristic of all other algae.

Rather than introducing small chunks of DNA as other viruses do, some giant viruses can contribute more than 1 million base pairs to a host’s genome, broadening the ways in which viruses may shape eukaryote evolution.

Far from being inert fat-storage depots within cells, these lipid-loaded organelles recruit immune proteins and block bacterial growth.

The 12-year-long endeavor reveals Prometheoarchaeum as a tentacled cell, living in a symbiotic relationship with methane-producing microbes.

The ancient organisms appear to be more closely related to eukaryotes than previously appreciated.

Identification of new archaea species elucidates the domain’s unique  biology and sheds light on its relationship to eukaryotes.

The 10-micrometer-long flagellate cell might have a big story to tell about the evolution of eukaryotes.

Did endosymbiosis—and the innovations in membrane bioenergetics it engendered—make it possible for eukaryotic life to evolve?

Deep-sea microbes possess hallmarks of eukaryotic cells, hinting at a common ancestor for archaea and eukaryotes.

A red alga appears to have adapted to extremely hot, acidic environments by collecting genes from bacteria and archaea.

In the largest microbial eukaryote genetic sequencing effort ever attempted, researchers are investigating the transcriptomes of 700 marine algae species.

A single-celled relative of animals forms colonies when exposed to a bacterial product, hinting at the possible origins of multicellularity.

Researchers investigate a microorganism that may warrant a new eukaryotic kingdom in the classification of life.

An insect that plagues coffee plants likely got its bean-digesting gene from a bacterium.