genome architecture

A study employing CRISPR/Cas9 to explore the evolutionary beginnings of some giant viruses finds evidence their large genomes arose from gene duplications.

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.

The transcription of DNA drives the remarkably tidy organization of chromosomes in the dinoflagellate Symbiodinium microadriaticum.

Saccharomyces cerevisiae showed only minor alterations in growth and gene expression when its 16 chromosomes were combined.

A new full-genome map indicates how DNA is folded within the nuclei of human cells.

Three-dimensional genome maps are leading to a deeper understanding of how the genome’s form influences its function.